Seroatlas · Human Serome Atlas

ZNF736

Zinc finger protein 736

Also known as: ZN736_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B4DX44
Gene: ZNF736
Ensembl: ENSG00000234444
Chromosome: 7
Canonical length: 427 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

427 residues, UniProt reviewed canonical sequence.

>B4DX44|ZNF736
     1  MGVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL VSLGLAIFKP DLMTCLEQRK
    61  EPWKVKRQEA VAKHPAGSFH FTAEILPDHD IKDSFQKVIL RKYGSCDLNN LHLKKDYQSV
   121  GNCKGQKSSY NGLHQCLSAT HSKTCQCNKC GRGFQLCSIF TEHKDIFSRE KCHKCEECGK
   181  DCRLFSDFTR HKKIHTVERC YKCEECGKAF KKFSNLTEHK RVHTGEKPYK CEGCGKTFTC
   241  SSTLVKHKRN HTGDRPYKCE ECGKAFKCFS DLTNHKRIHT GEKPYKCEEC NKAYRWFSDL
   301  AKHKIIHTGD KPYTCNECGK AFKWFSALSK HKRIHTGEKP YICEECGKAF TRSSTLFNHK
   361  RIHMEERPYK CEECSKTFKC FSDLTNHKRI HTGEKPYKCE ECGKASSWFS HLIRHKRIHT
   421  REKLHKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF736 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
bone marrow: 7.2 nTPM
testis: 6.4 nTPM
skin: 4.4 nTPM
lymph node: 3.9 nTPM
ovary: 3.9 nTPM

Single-cell type

rod photoreceptor cells: 125 nCPM
late spermatids: 101 nCPM
podocytes: 94 nCPM
pdcs: 73 nCPM
corticotrophs: 69 nCPM
b-cells: 66 nCPM

Immune cell

memory B-cell: 1.8 nTPM
naive B-cell: 1.4 nTPM
plasmacytoid DC: 1.2 nTPM
eosinophil: 1.1 nTPM
myeloid DC: 0.7 nTPM
intermediate monocyte: 0.6 nTPM

Brain region

cerebral cortex: 21 nTPM
basal ganglia: 19 nTPM
white matter: 19 nTPM
hypothalamus: 19 nTPM
amygdala: 18 nTPM
cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF736 as an antibody target. Whether an autoantibody or antibody against ZNF736 could matter depends on whether native ZNF736 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF736 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF736 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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