ZNF735
Zinc finger protein 735
Also known as: ZN735_HUMAN, ZNF735P
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0CB33
- Gene
- ZNF735
- Ensembl
- ENSG00000223614
- Chromosome
- 7
- Canonical length
- 412 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and nine C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
Canonical amino-acid sequenceUniProt
412 residues, UniProt reviewed canonical sequence.
>P0CB33|ZNF735
1 MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR NLFSLGMTVS
61 KPDLIACLEQ NKEPQNIKRN EMAAKHPVTC SHFNQDLQPE QSIKDSLQKV IPRTYGKCGH
121 ENLQLKKCCK RVDECEVHKG GYNDLNQCLS NTQNKIFQTH KCVKVFSKFS NSNRHNARYT
181 GKKHLKCKKY GKSFCMFSHL NQHQIIHTKE KSYKCEECGK SFNHSSSGTT HKRILTGEKP
241 YRCEECGKAF RWPSNLTRHK RIHTGEKPYA CEECGQAFRR SSTLTNHKRI HTGERPYKCE
301 ECGKAFSVSS ALIYHKRIHT GEKPYTCEEC GKAFNCSSTL KTHKIIHTGE KPYTCEECGR
361 TFNCSSTVKA HKRIHTGEKP YKCEECDKAF KWHSSLAKHK IIHTGEKPYK CKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF735 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- early spermatids: 1.8 nCPM
- differentiating spermatogonia: 0.9 nCPM
- late primary spermatocytes: 0.5 nCPM
- undifferentiated spermatogonia: 0.5 nCPM
- basal keratinocytes: 0.3 nCPM
- salivary myoepithelial cells: 0.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF735 as an antibody target. Whether an autoantibody or antibody against ZNF735 could matter depends on whether native ZNF735 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF735 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF735 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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