Seroatlas · Human Serome Atlas

ZNF732

Zinc finger protein 732

Also known as: FLJ59067, ZN732_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B4DXR9
Gene: ZNF732
Ensembl: ENSG00000186777
Chromosome: 4
Canonical length: 585 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and sixteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>B4DXR9|ZNF732
     1  MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL ISLGVAISNP DLVIYLEQRK
    61  EPYKVKIHET VAKHPAVCSH FTQDFLPVQG IEDSFHKLIL RRYEKCGHEN LELRKSCKRK
   121  VQKGGYNEFN QCLSTIQSKI FQCNVHVKVF STFSNSNQRR IRHTGEKHFK ECGKSFQKFS
   181  DLTQHQGIHA GEKPYTCEEC GKDFKWYLIF NEYEIIHTGE KPFTCEECGN IFTTSSNFAK
   241  HKVHTGEKSY KYEECGKAFN RSSTLTKHKR IHAEEKPFTC EECGKIITSS SNVAKHKKIH
   301  TGEKLYKCQE CGKVFNRSTT LTKHNRIHTG EKPYTCEECG KAFSRSSVLN EHKRIHTGEK
   361  PYKCEQCGKA FRQSATLNKH KSIHTGEKPY TCEECGKAFS RFTTLNEHKR IHTGERPHKC
   421  EECGKAFGWS TDLNKHKIIH TGEKPYKCEE CGKAFGWSAY LSKHKKIHTG EKPYRCEECG
   481  KAFLCSRALN KHKTIHTGEK PYECEECGKA FGWSTYLSKH KKIHTGEKPY RCEECGKAFR
   541  RSRVLNKYKT IHTGDKTPKC KGCGKAFKWS SYLNQHNKIY TGEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF732 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 1.5 nTPM
testis: 1.4 nTPM
ovary: 0.8 nTPM
retina: 0.8 nTPM
pituitary gland: 0.7 nTPM
skin: 0.6 nTPM

Single-cell type

early primary spermatocytes: 28 nCPM
differentiating spermatogonia: 24 nCPM
cardiomyocytes: 11 nCPM
oocytes: 9.2 nCPM
undifferentiated spermatogonia: 8.2 nCPM
brain inhibitory neurons: 8.1 nCPM

Immune cell

basophil: 0.1 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 3.7 nTPM
cerebral cortex: 3 nTPM
cerebellum: 2.9 nTPM
hypothalamus: 2.5 nTPM
amygdala: 2.4 nTPM
hippocampal formation: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.1
gnomAD missense Z: -0.52
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF732 as an antibody target. Whether an autoantibody or antibody against ZNF732 could matter depends on whether native ZNF732 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF732 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF732 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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