Seroatlas · Human Serome Atlas

ZNF730

Putative zinc finger protein 730

Also known as: ZN730_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMV8
Gene: ZNF730
Ensembl: ENSG00000183850
Chromosome: 19
Canonical length: 503 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q6ZMV8|ZNF730
     1  MGALTFRDVA IEFSLEEWQC LDTEQQNLYR NVMLDNYRNL VFLGIAVSKP DLITCLEQEK
    61  EPWNLKTHDM VAKPPVICSH IAQDLWPEQG IKDYFQEVIL RQYKKCRHEN LLLRKGCKNV
   121  DEFKMHKKGY NRHNQCLTTS HSKIFQCDKY VKVFHKFSNS NRHKIRHTSK KPFKCKECGK
   181  LFCILSHLAQ HKKIHTGEKS YKCEEYGKAF NESSNCTTHK RITEKKPYKC KECGKAFNWF
   241  SHFTTHKRIH TGEKPYQCEK CGKFFNQSTN LTTHKRIHTG EKPYKCEECG KAFNQSSNLT
   301  EHKKIHTKEQ PYKCEKCGKA FKWSSTLTKH KRIHNGEKPY KCEECGKAFN RSSTLNRHKI
   361  THTGGKPYKY KECGKAFNQS STLTIHKIIH TVEKFYKCEE CGKAFSRISH LTTHKRIHTG
   421  EKPYKCEECG RAFNQSSTLT THKRIHTGEK PYECEECGKA FNRSSTLTTH KIIHSGEKIY
   481  KCKECGKAFR RFSHLTRHKT IHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF730 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

testis: 4.7 nTPM
thymus: 2.4 nTPM
ovary: 2 nTPM
tonsil: 1.9 nTPM
lymph node: 1.7 nTPM
placenta: 1.7 nTPM

Single-cell type

early spermatids: 66 nCPM
megakaryocyte progenitors: 54 nCPM
late spermatids: 37 nCPM
oligodendrocyte progenitor cells: 32 nCPM
syncytiotrophoblasts: 29 nCPM
megakaryocyte-erythroid progenitors: 26 nCPM

Immune cell

naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 14 nTPM
pons: 13 nTPM
midbrain: 13 nTPM
medulla oblongata: 12 nTPM
white matter: 9.8 nTPM
basal ganglia: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -0.92
DepMap mean gene effect: -0.31
DepMap dependency class: selective

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF730 as an antibody target. Whether an autoantibody or antibody against ZNF730 could matter depends on whether native ZNF730 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF730 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF730 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...