Seroatlas · Human Serome Atlas

ZNF729

Zinc finger protein 729

Also known as: ZN729_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NN14
Gene: ZNF729
Ensembl: ENSG00000196350
Chromosome: 19
Canonical length: 1252 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1252 residues, UniProt reviewed canonical sequence.

>A6NN14|ZNF729
     1  MPGAPGSLEM GPLTFRDVTI EFSLEEWQCL DTVQQNLYRD VMLENYRNLV FLGMAVFKPD
    61  LITCLKQGKE PWNMKRHEMV TKPPVMRSHF TQDLWPDQST KDSFQEVILR TYARCGHKNL
   121  RLRKDCKSAN EGKMHKEGYN KLNQCRTATQ RKIFQCNKHM KVFHKYSNRN KVRHTKKKTF
   181  KCIKCSKSFF MLSCLIRHKR IHIRQNIYKC EERGKAFKSF STLTKHKIIH TEDKPYKYKK
   241  CGNAFKFSST FTKHKRIHTG ETPFRCEECG KAFNQSSNLT DHKRIHTGEK TYKCEECGKA
   301  FKGSSNFNAH KVIHTAEKPY KCEDCGKTFN HFSALRKHKI IHTGKKPYKR EECGKAFSQS
   361  STLRKHEIIH TGEKPYKCEE CGKAFKWSSK LTVHKVVHTG EKPYKCEECG KAFSQFSTLK
   421  KHKIIHTGKK PYKCEECGKA FNSSSTLMKH KIIHTGEKPY KCEECGKAFR QSSHLTRHKA
   481  IHTGEKPYKC EECGKAFNHF SDLRRHKIIH TGKKPYKCEE CGKAFSQSST LRNHQIIHTG
   541  EKPYKCEECG KAFKWSSKLT VHKVIHTGEK PCKCEECGKA FKHFSALRKH KVIHTREKLY
   601  KCEECGKAFN NSSILAKHKI IHTGKKPYKC EECGKAFRQS SHLTRHKAIH TGEKPYKCEE
   661  CGKAFSHFSA LRRHKIIHTG KKPYKCEECG KAFSHFSALR RHKIIHTGEK PYKCEECGKA
   721  FKWSSKLTVH KVIHTAEKPC KCEECGKSFK HFSALRKHKV IHTREKLYKC EECVKAFNSF
   781  SALMKHKVIH TGEKPYKCEE CGKAFKWSSK LTVHKVIHTG EKPCKCEECG KAFKHFSALR
   841  KHKVIHTGKK PYKCEECGKA FSQSSSLRKH EIIHSGEKPY KCEECGKAFK WLSKLTVHKV
   901  IHTAEKPCKC EECGKAFKHF SALRKHKIIH TGKKPYKCEE CGKAFNDSST LMKHKIIHTG
   961  KKPYKCAECG KAFKQSSHLT RHKAIHTGEK PYKCEECGKD FNNSSTLKKH KLIHTREKLY
  1021  KCEECVKAFN NFSALMKHKI IHTGEKPYKC EECGKAFKWS SKLTEHKVIH TGEKPCKCEE
  1081  CDKAFKHFSA LRKHKVIHTG KKPYQCDECG KAFNNSSTLT KHKIIHTGEK PYKCEECGKA
  1141  FSQSSILTKH KIIHSVEKPY KCEECGKAFN QSSHLTRHKT IHTGEKPYKC EECGKAFIQC
  1201  SYLIRHKTIH TREKPTNVKK VPKLLSNPHT LLDKTIHTGE KPYKCEECAK AF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF729 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
breast: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

differentiating spermatogonia: 7.4 nCPM
early primary spermatocytes: 6.9 nCPM
late primary spermatocytes: 3.2 nCPM
undifferentiated spermatogonia: 2.9 nCPM
late spermatids: 1.7 nCPM
early spermatids: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.4
gnomAD missense Z: -1.59
DepMap mean gene effect: 0.13
DepMap dependency class: none

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF729 as an antibody target. Whether an autoantibody or antibody against ZNF729 could matter depends on whether native ZNF729 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF729 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF729 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...