Seroatlas · Human Serome Atlas

ZNF727

Zinc finger protein 727

Also known as: ZN727_HUMAN, ZNF727P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MUV8
Gene: ZNF727
Ensembl: ENSG00000214652
Chromosome: 7
Canonical length: 499 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>A8MUV8|ZNF727
     1  MRVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL FSLGLAIFKP DLITYLEQRK
    61  EPWNARRQKT VAKHPAGSLH FTAEILLEHD INDSFQKVIL RKSGSCDLNT LRLKKDYQRV
   121  GNCKGQKSSY NGIHQCLSAT RSKTCQYNKC GKAFGLCSIF TEHKKIFSRE KCYKCEECGK
   181  DCRLSDFTIQ KRIHTADRSY KCEECGKACK KFSNLTEHNR VHTGKKPYKC EECGKTFTCS
   241  SALTKHKRNH TGDRPYKCEE CHKAFRCCSD LTKHKRIHTG EKPYKCKECH KAFRCCSDLT
   301  KHKRIHTGEK PYKCNECGKA FMWISALSQH NRIHTGEKPY ICEECGKAFT YSSTLISHKR
   361  IHMELRPYKC EECGKTFKWF SDLTNHKRIH TGEKPYKCEE CGKSFTCSSN LIKHKRIHME
   421  VRPYKCEECG KTFKWFPDLT NHKRIHTGEK PYKCEECGKT FTCSSSLIKH KRSHTGDRPT
   481  SAKNVAKPLG GSQTLLNIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF727 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

retina: 3.3 nTPM
thyroid gland: 2.9 nTPM
ovary: 2.6 nTPM
epididymis: 2.5 nTPM
breast: 2.2 nTPM
cerebellum: 2.2 nTPM

Single-cell type

podocytes: 29 nCPM
renal collecting duct principal cells: 18 nCPM
renal connecting tubule cells: 16 nCPM
loop of henle epithelial cells: 13 nCPM
papillary tip epithelial cells: 13 nCPM
distal convoluted tubule cells: 12 nCPM

Immune cell

naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 12 nTPM
cerebellum: 11 nTPM
white matter: 10 nTPM
cerebral cortex: 10 nTPM
midbrain: 10 nTPM
basal ganglia: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF727 as an antibody target. Whether an autoantibody or antibody against ZNF727 could matter depends on whether native ZNF727 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF727 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF727 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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