Seroatlas · Human Serome Atlas

ZNF724

Zinc finger protein 724

Also known as: ZN724_HUMAN, ZNF724P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTY0
Gene: ZNF724
Ensembl: ENSG00000196081
Chromosome: 19
Canonical length: 619 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>A8MTY0|ZNF724
     1  MGPLTFMDVA IEFSVEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQGK
    61  EPWNMERHEM VAKPPGMCCY FAQDLRPEQS IKASLQRIIL RKYEKCGHHN LQLKKGYKSV
   121  DEYKVHKGSY NGFNQCLTTT QSKIFQCDKY VKDFHKFSNS NRHKTEKNPF KCKECGKSFC
   181  VLSHLTQHKR IHTTVNSYKL EECGKAFNVS STLSQHKRIH TGQKHYKCEE CGIAFNKSSH
   241  LNTHKIIHTG EKSYKREECG KAFNISSHLT THKIIHTGEN AYKCKECGKA FNQSSTLTRH
   301  KIIHAGEKPY ICEHCGRAFN QSSNLTKHKR IHTGDKPYKC EECGKAFNVS STLTQHKRIH
   361  TGEKPYKCEE CGKAFNVSST LTQHKRIHTG EKPYKCEECG KAFNTSSHLT THKRIHTGEK
   421  PYKCEECGKA FNQFSQLTTH KIIHTGEKPY KCKECGKAFK RSSNLTEHRI IHTGEKPYKC
   481  EECGKAFNLS SHLTTHKKIH TGEKPYKCKE CGKAFNQSST LARHKIIHAG EKPYKCEECG
   541  KAFYQYSNLT QHKIIHTGEK PYKCEECGKA FNWSSTLTKH KVIHTGEKPY KCKECGKAFN
   601  QCSNLTTHKK IHAVEKSDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF724 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 2.6 nTPM
esophagus: 2.4 nTPM
stomach: 1.6 nTPM
testis: 0.9 nTPM
thymus: 0.8 nTPM
tonsil: 0.8 nTPM

Single-cell type

megakaryocytes: 12 nCPM
erythrocyte progenitors: 12 nCPM
early primary spermatocytes: 10 nCPM
differentiating spermatogonia: 9.2 nCPM
oocytes: 9.2 nCPM
megakaryocyte progenitors: 7.9 nCPM

Immune cell

neutrophil: 2.4 nTPM
basophil: 2.3 nTPM
NK-cell: 2 nTPM
naive B-cell: 1.9 nTPM
memory B-cell: 1.5 nTPM
plasmacytoid DC: 1.4 nTPM

Brain region

cerebellum: 9.4 nTPM
white matter: 7.2 nTPM
hypothalamus: 7 nTPM
pons: 6.9 nTPM
cerebral cortex: 6.7 nTPM
midbrain: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0.11

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF724 as an antibody target. Whether an autoantibody or antibody against ZNF724 could matter depends on whether native ZNF724 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF724 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF724 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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