Seroatlas · Human Serome Atlas

ZNF723

Zinc finger protein 723

Also known as: ZN723_HUMAN, ZNF723P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPD5
Gene: ZNF723
Ensembl: ENSG00000268696
Chromosome: 19
Canonical length: 513 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>P0DPD5|ZNF723
     1  MGPLTFTDVA IKFSLEEWQF LDTAQQNLYR DVMLENYRNL VFLGVGVSKP DLITCLEQGK
    61  EPWNMKRHKM VAKPPVVCSH FAQDLWPEQG IKDSFQKVIL RSYGKYGHDN LQLRKGCESV
   121  DECKMHKGGY DELKQCLTTT PSKIFQCDKY VKVFHKFSSS NSQKIRHTGN NSFKCKECGK
   181  SFCMLSHLTK HERNHTRVNC YKCEECGKAF SVPSKLNNHK RIHTGEKPYK CEECGKAFNV
   241  SSSLNNHKRI HTGEKPYKCE ECGKTFNMFS SLNNHKRIHT GEKPYKCKEC GKAFNVFSSL
   301  NNHKRIHTGE KPYKCEECGK AFNQPSHLAT HKRIHTGEKL YKCEECGKAF SQSSHITTHK
   361  RIHTGEKPYK CEECGKAFKV SVHLTTHKRI HTGEKPYKCE ECGKAFNQSS ALTTHKIIHT
   421  GERPYKCKQC GKGFSQSSTL TKHKIIHTKE KPYKCEECGK AFNQYSTLNK HKIIHAREKP
   481  YKCEECGKAF NKSSILNRHK IIHTKEKSQT LKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF723 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

testis: 3.1 nTPM
epididymis: 0.3 nTPM
parathyroid gland: 0.2 nTPM
bone marrow: 0.1 nTPM
pancreas: 0.1 nTPM
placenta: 0.1 nTPM

Single-cell type

early spermatids: 59 nCPM
early primary spermatocytes: 31 nCPM
late primary spermatocytes: 18 nCPM
differentiating spermatogonia: 12 nCPM
oocytes: 4.6 nCPM
late spermatids: 4 nCPM

Immune cell

basophil: 0.9 nTPM
neutrophil: 0.4 nTPM
eosinophil: 0.3 nTPM
naive B-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 0.9 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM
cerebral cortex: 0.7 nTPM
midbrain: 0.7 nTPM
pons: 0.7 nTPM

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF723 as an antibody target. Whether an autoantibody or antibody against ZNF723 could matter depends on whether native ZNF723 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF723 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF723 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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