Seroatlas · Human Serome Atlas

ZNF721

Zinc finger protein 721

Also known as: KIAA1982, ZN721_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF20
Gene: ZNF721
Ensembl: ENSG00000182903
Chromosome: 4
Canonical length: 911 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

911 residues, UniProt reviewed canonical sequence.

>Q8TF20|ZNF721
     1  MCSHFTQDFL PVQGIEDSFH KLILRRYEKC GHDNLQLRKG CKSMNVCKVQ KGVYNGINKC
    61  LSNTQSKIFQ CNARVKVFSK FANSNKDKTR HTGEKHFKCN ECGKSFQKFS DLTQHKGIHA
   121  GEKPYTCEER GKDFGWYTDL NQHKKIHTGE KPYKCEECGK AFNRSTNLTA HKRIHNREKA
   181  YTGEDRDRAF GWSTNLNEYK KIHTGDKPYK CKECGKAFMH SSHLNKHEKI HTGEKPYKCK
   241  ECGKVISSSS SFAKHKRIHT GEKPFKCLEC GKAFNISTTL TKHRRIHTGE KPYTCEVCGK
   301  AFRQSANLYV HRRIHTGEKP YTCGECGKTF RQSANLYVHR RIHTGEKPYK CEDCGKAFGR
   361  YTALNQHKKI HTGEKPYKCE ECGKAFNSST NLTAHKRIHT REKPYTCEDR GRAFGLSTNL
   421  NEYKKIHTGD KPYKCKECGK AFIHSLHLNK HEKIHTGKKP YKCKQCGKVI TSSSSFAKHK
   481  RIHTGEKPFE CLECGKAFTS STTLTKHRRI HTGEKPYTCE VCGKAFRQSA ILYVHRRIHT
   541  GEKPYTCEEC GKTFRQSANL YVHRRIHTGE KPYKCEECGK AFGRYTDLNQ HKKIHTGEKL
   601  YKCEECGKDF VWYTDLNQQK KIYTGEKPYK CEECGKAFAP STDLNQHTKI LTGEQSYKCE
   661  ECGKAFGWSI ALNQHKKIHT GEKPYKCEEC GKAFSRSRNL TTHRRVHTRE KPYKCEDRGR
   721  SFGWSTNLNE YKKIHTGDKL YKCKECGKVF KQSSHLNRHE KIHTGKKPYK CKECGKVITS
   781  SSSFAKHKRI HTGEKPFKCL ECGKAFTSST TLTKHRRIHT GEKPYTCEEC GKAFRQSAIL
   841  YVHRRIHTGE KPYTCGECGK TFRQSANLYA HKKIHTGEKP YTCGDCGKTF RQSANLYAHK
   901  KIHTGDKTIQ V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF721 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

lymph node: 21 nTPM
tonsil: 21 nTPM
cerebellum: 19 nTPM
retina: 18 nTPM
thymus: 18 nTPM
breast: 18 nTPM

Single-cell type

distal convoluted tubule cells: 233 nCPM
podocytes: 205 nCPM
proximal tubule cells: 204 nCPM
renal collecting duct intercalated cells: 201 nCPM
renal connecting tubule cells: 187 nCPM
loop of henle epithelial cells: 179 nCPM

Immune cell

naive CD4 T-cell: 21 nTPM
memory B-cell: 17 nTPM
T-reg: 17 nTPM
naive CD8 T-cell: 17 nTPM
naive B-cell: 16 nTPM
NK-cell: 14 nTPM

Brain region

cerebellum: 64 nTPM
cerebral cortex: 51 nTPM
white matter: 49 nTPM
hypothalamus: 43 nTPM
basal ganglia: 43 nTPM
amygdala: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.09
gnomAD missense Z: -1.77
DepMap mean gene effect: 0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF721 as an antibody target. Whether an autoantibody or antibody against ZNF721 could matter depends on whether native ZNF721 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF721 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF721 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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