Seroatlas · Human Serome Atlas

ZNF718

Zinc finger protein 718

Also known as: FLJ90036, ZN718_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SXZ3
Gene: ZNF718
Ensembl: ENSG00000250312
Chromosome: 4
Canonical length: 478 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q3SXZ3|ZNF718
     1  MELLTFKDVA IEFSPEEWKC LDTSQQNLYR DVMLENYRNL VSLGVSISNP DLVTSLEQRK
    61  EPYNLKIHET AARPPAVCSH FTQNLWTVQG IEDSFHKLIP KGHEKRGHEN LRKTCKSINE
   121  CKVQKGGYNR INQCLLTTQK KTIQSNICVK VFHKFSNSNK DKIRYTGDKT FKCKECGKSF
   181  HVLSRLTQHK RIHTGENPYT CEECGKAFNW SSILTKHKRI HAREKFYKCE ECGKGFTRSS
   241  HLTKHKRIHT GEKPYICEKC GKAFNQSSTL NLHKRIHSAQ KYYKCEECGK AFKWSSSLNE
   301  HKRIHAGEKP FSCEECGNVF TTSSDFAKHK RIHTGEKPYK CEECGKSFNR STTLTTHKRI
   361  HTGEKPYTCE ECGKAFNWSS TLNVHKRIHS GKNPYKCEDC GKAFKVFANL HNHKKIHTGE
   421  KPYICKQCGK AFKQSSHLNK HKKIHTVDKP YKCKECGKAF KQYSNLPQHK RTHTGGKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF718 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 4.4 nTPM
thymus: 4.3 nTPM
lymph node: 3.6 nTPM
tonsil: 3.2 nTPM
cervix: 3.1 nTPM
ovary: 3 nTPM

Single-cell type

sertoli cells: 171 nCPM
hematopoietic stem cells: 140 nCPM
lactotrophs: 130 nCPM
thymocytes: 122 nCPM
neutrophil progenitors: 112 nCPM
thyrotrophs: 107 nCPM

Immune cell

eosinophil: 5.7 nTPM
NK-cell: 5.4 nTPM
basophil: 2.7 nTPM
myeloid DC: 2.4 nTPM
plasmacytoid DC: 2.4 nTPM
gdT-cell: 2.2 nTPM

Brain region

cerebellum: 17 nTPM
midbrain: 16 nTPM
white matter: 16 nTPM
thalamus: 16 nTPM
cerebral cortex: 15 nTPM
pons: 15 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF718 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF718 as an antibody target. Whether an autoantibody or antibody against ZNF718 could matter depends on whether native ZNF718 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF718 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF718 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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