Seroatlas · Human Serome Atlas

ZNF717

Zinc finger protein 717

Also known as: X17, ZN717_HUMAN, ZNF838

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY31
Gene: ZNF717
Ensembl: ENSG00000227124
Chromosome: 3
Canonical length: 914 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane

OverviewNCBI Gene

This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

914 residues, UniProt reviewed canonical sequence.

>Q9BY31|ZNF717
     1  MFPVFSGCFQ ELQEKNKSLE LVSFEEVAVH FTWEEWQDLD DAQRTLYRDV MLETYSSLVS
    61  LGHYITKPEM IFKLEQGAEP WIVEETPNLR LSAVQIIDDL IERSHESHDR FFWQIVITNS
   121  NTSTQERVEL GKTFNLNSNH VLNLIINNGN SSGMKPGQFN DCQNMLFPIK PGETQSGEKP
   181  HVCDITRRSH RHHEHLTQHH KIQTLLQTFQ CNEQGKTFNT EAMFFIHKRV HIVQTFGKYN
   241  EYEKACNNSA VIVQVITQVG QPTCCRKSDF TKHQQTHTGE KPYECVECEK PSISKSDLML
   301  QCKMPTEEKP YACNWCEKLF SYKSSLIIHQ RIHTGEKPYG CNECGKTFRR KSFLTLHERT
   361  HTGDKPYKCI ECGKTFHCKS LLTLHHRTHS GEKPYQCSEC GKTFSQKSYL TIHHRTHTGE
   421  KPYACDHCEE AFSHKSRLTV HQRTHTGEKP YECNECGKPF INKSNLRLHQ RTHTGEKPYE
   481  CNECGKTFHR KSFLTIHQWT HTGEKPYECN ECGKTFRCKS FLTVHQRTHA GEKPYACNEC
   541  GKTYSHKSYL TVHHRTHTGE KPYECNECGK SFHCKSFLTI HQRTHAGKKP YECNECEKTF
   601  INKLNLGIHK RTHTGERPYE CNECGKTFRQ KSNLSTHQGT HTGEKPYVCN ECGKTFHRKS
   661  FLTIHQRTHT GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN PFIRRQIFRS
   721  IKVFTRGRNP MNVANVEKPC QKSVLTVHHR THTGEKPYEC NECGKTFCHK SNLSTHQGTH
   781  SGEKPYECDE CRKTFYDKTV LTIHQRTHTG EKPFECKECR KTFSQKSKLF VHHRTHTGEK
   841  PFRCNECRKT FSQKSGLSIH QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA
   901  EAGYVFPQNH SFFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF717 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

epididymis: 15 nTPM
skin: 9.4 nTPM
thyroid gland: 8.9 nTPM
kidney: 8.8 nTPM
pituitary gland: 8.2 nTPM
parathyroid gland: 7.9 nTPM

Single-cell type

ependymal cells: 116 nCPM
astrocytes: 102 nCPM
bergmann glia: 101 nCPM
oligodendrocyte progenitor cells: 89 nCPM
retinal ganglion cells: 85 nCPM
adipocytes: 78 nCPM

Immune cell

naive CD4 T-cell: 6.3 nTPM
naive B-cell: 6.1 nTPM
eosinophil: 5.2 nTPM
memory B-cell: 5.1 nTPM
plasmacytoid DC: 4.1 nTPM
intermediate monocyte: 3.8 nTPM

Brain region

white matter: 28 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 23 nTPM
pons: 22 nTPM
thalamus: 22 nTPM
spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0.02
gnomAD missense Z: -1.91

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF717 as an antibody target. Whether an autoantibody or antibody against ZNF717 could matter depends on whether native ZNF717 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF717 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF717 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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