Seroatlas · Human Serome Atlas

ZNF714

Zinc finger protein 714

Also known as: ZN714_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N38
Gene: ZNF714
Canonical length: 554 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZNF714 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>Q96N38|ZNF714
     1  MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC SSFTRDLWPE
    61  QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK GYELNQCLTT TQSKIFPCDK
   121  YIKVFHKIFN SNRHKTRHTG EKPFKCKKCD ESFCMLLHLH QHKRIHIREN SYQCEECDKV
   181  FKRFSTLTRH KRVHTGEKPF KCEECGKAFK HSSTLTTHKM IHTGEKPYRC EECGKAFYHS
   241  SHLTTHKVIH TGEKPFKCEE CGKAFNHPSA LTTHKFIHVK EKPYKCEECD KAFNRFSYLT
   301  KHKIIHSGEK SYKCEQCGKG FNWSSTLTKH KRIHTGEKPY KCEECGKAFN VSSHLTTHKM
   361  IHTGEKPYKC EECGKAFNHS SKLTIHKIIH TGEKPYKCEE CGKAFNQSSN LTKHKIIHTG
   421  EKLYKCEECG KAFNRSSNLT THKRIHTGEK PYKCEECGKA FNRSSNLTKH NIIHTGEKSY
   481  KCEECGKAFN QSSTLTKHRK IQQGMVAHAC NPNTLRGLGE QIARSGVQDQ PGQHGKTPSL
   541  LKIQKFAGCG GRRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF714 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

ovary: 14 nTPM
thyroid gland: 13 nTPM
bone marrow: 6.5 nTPM
cerebellum: 6.2 nTPM
skin: 6.2 nTPM
thymus: 5.3 nTPM

Single-cell type

esophageal apical cells: 102 nCPM
adrenal cortex cells: 94 nCPM
retinal pigment epithelial cells: 90 nCPM
alveolar cells type 1: 82 nCPM
retinal ganglion cells: 73 nCPM
early primary spermatocytes: 73 nCPM

Immune cell

plasmacytoid DC: 7.8 nTPM
basophil: 5.1 nTPM
eosinophil: 4.9 nTPM
naive CD4 T-cell: 4.4 nTPM
naive CD8 T-cell: 3.9 nTPM
T-reg: 3.6 nTPM

Brain region

cerebellum: 25 nTPM
basal ganglia: 18 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 15 nTPM
pons: 15 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.04
gnomAD missense Z: -0.41
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF714 as an antibody target. Whether an autoantibody or antibody against ZNF714 could matter depends on whether native ZNF714 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF714 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF714 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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