Seroatlas · Human Serome Atlas

ZNF713

Zinc finger protein 713

Also known as: FLJ39963, ZN713_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N859
Gene
ZNF713
Ensembl
ENSG00000178665
Chromosome
7
Canonical length
443 aa
Protein class
Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli

OverviewNCBI Gene

The protein encoded by this gene contains C2H2 zinc finger domains. In some individuals, a CGG-repeat expansion from 5-22 repeats to 68-450 repeats has been identified in the first intron of this gene. This mutation is thought to effect the expression of this gene and it has been proposed that it may be associated with Autistic Spectrum Disorder. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q8N859|ZNF713
     1  MPSQNAVFSQ EGNMEEEEMN DGSQMVRSQE SLTFQDVAVD FTREEWDQLY PAQKNLYRDV
    61  MLENYRNLVA LGYQLCKPEV IAQLELEEEW VIERDSLLDT HPDGENRPEI KKSTTSQNIS
   121  DENQTHEMIM ERLAGDSFWY SILGGLWDFD YHPEFNQENH KRYLGQVTLT HKKITQERSL
   181  ECNKFAENCN LNSNLMQQRI PSIKIPLNSD TQGNSIKHNS DLIYYQGNYV RETPYEYSEC
   241  GKIFNQHILL TDHIHTAEKP SECGKAFSHT SSLSQPQMLL TGEKPYKCDE CGKRFSQRIH
   301  LIQHQRIHTG EKPFICNGCG KAFRQHSSFT QHLRIHTGEK PYKCNQCGKA FSRITSLTEH
   361  HRLHTGEKPY ECGFCGKAFS QRTHLNQHER THTGEKPYKC NECGKAFSQS AHLNQHRKIH
   421  TREKLCEYKC EQTVRHSPSF SST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF713 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.5 nTPM
  • cerebral cortex: 2.3 nTPM
  • retina: 2.2 nTPM
  • fallopian tube: 1.7 nTPM
  • ovary: 1.6 nTPM
  • skeletal muscle: 1.6 nTPM

Single-cell type

  • ependymal cells: 59 nCPM
  • oligodendrocytes: 47 nCPM
  • choroid plexus epithelial cells: 43 nCPM
  • oligodendrocyte progenitor cells: 30 nCPM
  • brain inhibitory neurons: 29 nCPM
  • bergmann glia: 26 nCPM

Immune cell

  • neutrophil: 2.8 nTPM
  • basophil: 1.7 nTPM
  • eosinophil: 1.5 nTPM
  • naive B-cell: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • white matter: 18 nTPM
  • medulla oblongata: 13 nTPM
  • pons: 13 nTPM
  • cerebellum: 13 nTPM
  • cerebral cortex: 13 nTPM
  • thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
1.01
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF713 as an antibody target. Whether an autoantibody or antibody against ZNF713 could matter depends on whether native ZNF713 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF713 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF713 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF713. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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