ZNF709
Zinc finger protein 709
Also known as: FLJ38281, ZN709_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N972
- Gene
- ZNF709
- Ensembl
- ENSG00000242852
- Chromosome
- 19
- Canonical length
- 641 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
641 residues, UniProt reviewed canonical sequence.
>Q8N972|ZNF709
1 MDSVVFEDVA VNFTQEEWAL LGPSQKKLYR DVMQETFVNL ASIGENWEEK NIEDHKNQGR
61 KLRSHMVERL CERKEGSQFG ETISQTPNPK PNKKTFTRVK PYECSVCGKD YMCHSSLNRH
121 MRSHTEHRSY EYHKYGEKSY ECKECGKRFS FRSSFRIHER THTGEKPYKC KQCGKAFSWP
181 SSFQIHERTH TGEKPYECKE CGKAFIYHTT FRGHMRMHTG EKPYKCKECG KTFSHPSSFR
241 NHERTHSGEK PYECKQCGKA FRYYQTFQIH ERTHTGEKPY QCKQCGKALS CPTSFRSHER
301 IHTGEKPYKC KKCGKAFSFP SSFRKHERIH TGEKPYDCKE CGKAFISLPS YRRHMIMHTG
361 NGPYKCKECG KAFDCPSSFQ IHERTHTGEK PYECKQCGKA FSCSSSFRMH ERTHTGEKPH
421 ECKQCGKAFS CSSSVRIHER THTGEKPYEC KQCGKAFSCS SSFRMHERIH TGEKPYECKQ
481 CGKAFSFSSS FRMHERTHTG EKPYECKQCG KAFSCSSSFR MHERTHTGEK PYECKQCGKA
541 FSCSSSIRIH ERTHTGEKPY ECKQCGKAFS CSSSVRMHER THTGVKPYEC KQCDKAFSCS
601 RSFRIHERTH TGEKPYACQQ CGKAFKCSRS FRIHERVHSG ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF709 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- testis: 15 nTPM
- retina: 2.9 nTPM
- cerebellum: 2.7 nTPM
- thyroid gland: 2.7 nTPM
- ovary: 2.4 nTPM
- basal ganglia: 2.2 nTPM
Single-cell type
- early spermatids: 29 nCPM
- late spermatids: 24 nCPM
- late primary spermatocytes: 5 nCPM
- mucous neck cells: 0.8 nCPM
- megakaryocyte progenitors: 0.2 nCPM
- b-cells: 0.1 nCPM
Immune cell
- basophil: 2.7 nTPM
- NK-cell: 2.5 nTPM
- naive CD4 T-cell: 2 nTPM
- memory CD4 T-cell: 1.5 nTPM
- MAIT T-cell: 1.4 nTPM
- naive CD8 T-cell: 1.4 nTPM
Brain region
- medulla oblongata: 7.8 nTPM
- hypothalamus: 6.7 nTPM
- cerebellum: 6.3 nTPM
- cerebral cortex: 5.9 nTPM
- midbrain: 5.5 nTPM
- hippocampal formation: 5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.86
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.91
- DepMap mean gene effect
- 0.15
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF709 as an antibody target. Whether an autoantibody or antibody against ZNF709 could matter depends on whether native ZNF709 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF709 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF709 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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