Seroatlas · Human Serome Atlas

ZNF708

Zinc finger protein 708

Also known as: KOX8, ZN708_HUMAN, ZNF15, ZNF15L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17019
Gene: ZNF708
Ensembl: ENSG00000182141
Chromosome: 19
Canonical length: 563 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>P17019|ZNF708
     1  MGPLTFMDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSNL DLITCLEQGK
    61  EPWNMKRHEM AAKPPAMCSH FAKDLRPEQY IKNSFQQVIL RRYGKCGYQK GCKSVDEHKL
   121  HKGGHKGLNR CVTTTQSKIV QCDKYVKVFH KYSNAKRHKI RHTGKNPFKC KECGKSFCML
   181  SQLTQHEIIH TGEKPYKCEE CGKAFKKSSN LTNHKIIHTG EKPYKCEECG KAFNQSSTLT
   241  RHKIIHTGEK LYKCEECGKA FNRSSNLTKH KIVHTGEKPY KCEECGKAFK QSSNLTNHKK
   301  IHTGEKPYKC GECGKAFTLS SHLTTHKRIH TGEKPYKCEE CGKAFSVFST LTKHKIIHTE
   361  EKPYKCEECG KAFNRSSHLT NHKVIHTGEK PYKCEECGKA FTKSSTLTYH KVIHTGKKPY
   421  KCEECGKAFS IFSILTKHKV IHTEDKPYKC EECGKTFNYS SNFTNHKKIH TGEKPYKCEE
   481  CGKSFILSSH LTTHKIIHTG EKPYKCKECG KAFNQSSTLM KHKIIHTGEK PYKCEECGKA
   541  FNQSPNLTKH KRIHTKEKPY KCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF708 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 11 nTPM
cerebral cortex: 9.6 nTPM
ovary: 8.7 nTPM
lymph node: 7.6 nTPM
midbrain: 7.4 nTPM
thyroid gland: 6 nTPM

Single-cell type

oligodendrocytes: 277 nCPM
retinal pigment epithelial cells: 183 nCPM
neutrophils: 146 nCPM
bergmann glia: 139 nCPM
oligodendrocyte progenitor cells: 100 nCPM
adipocytes: 95 nCPM

Immune cell

basophil: 14 nTPM
neutrophil: 8.6 nTPM
naive CD4 T-cell: 6.4 nTPM
memory CD8 T-cell: 6.3 nTPM
MAIT T-cell: 5.9 nTPM
naive CD8 T-cell: 5.8 nTPM

Brain region

white matter: 80 nTPM
medulla oblongata: 55 nTPM
basal ganglia: 55 nTPM
pons: 50 nTPM
midbrain: 45 nTPM
cerebellum: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF708 as an antibody target. Whether an autoantibody or antibody against ZNF708 could matter depends on whether native ZNF708 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF708 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF708 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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