Seroatlas · Human Serome Atlas

ZNF707

Zinc finger protein 707

Also known as: ZN707_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96C28
Gene
ZNF707
Ensembl
ENSG00000181135
Chromosome
8
Canonical length
371 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q96C28|ZNF707
     1  MDMAQEPVTF RDVAIYFSRE EWACLEPSQR ALYRDVMLDN FSSVAALGFC SPRPDLVSRL
    61  EQWEEPWVED RERPEFQAVQ RGPRPGARKS ADPKRPCDHP AWAHKKTHVR RERAREGSSF
   121  RKGFRLDTDD GQLPRAAPER TDAKPTAFPC QVLTQRCGRR PGRRERRKQR AVELSFICGT
   181  CGKALSCHSR LLAHQTVHTG TKAFECPECG QTFRWASNLQ RHQKNHTREK PFCCEACGQA
   241  FSLKDRLAQH RKVHTEHRPY SCGDCGKAFK QKSNLLRHQL VHTGERPFYC ADCGKAFRTK
   301  ENLSHHQRVH SGEKPYTCAE CGKSFRWPKG FSIHRRLHLT KRFYECGHCG KGFRHLGFFT
   361  RHQRTHRHGE V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF707 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
7.6 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 7.6 nTPM
  • testis: 7.1 nTPM
  • skin: 5.4 nTPM
  • thyroid gland: 4.3 nTPM
  • kidney: 4.2 nTPM
  • small intestine: 4 nTPM

Single-cell type

  • podocytes: 9.3 nCPM
  • proximal tubule cells: 7.9 nCPM
  • loop of henle epithelial cells: 7.2 nCPM
  • distal convoluted tubule cells: 6.8 nCPM
  • renal collecting duct principal cells: 6.6 nCPM
  • renal connecting tubule cells: 6.4 nCPM

Immune cell

  • NK-cell: 0.9 nTPM
  • gdT-cell: 0.5 nTPM
  • eosinophil: 0.4 nTPM
  • MAIT T-cell: 0.4 nTPM
  • T-reg: 0.4 nTPM
  • basophil: 0.3 nTPM

Brain region

  • cerebral cortex: 4.7 nTPM
  • choroid plexus: 4.5 nTPM
  • white matter: 4.3 nTPM
  • thalamus: 4 nTPM
  • medulla oblongata: 3.9 nTPM
  • amygdala: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF707 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF707 as an antibody target. Whether an autoantibody or antibody against ZNF707 could matter depends on whether native ZNF707 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF707 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF707 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF707. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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