Seroatlas · Human Serome Atlas

ZNF706

Zinc finger protein 706

Also known as: HSPC038, ZN706_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5V0
Gene: ZNF706
Ensembl: ENSG00000120963
Chromosome: 8
Canonical length: 76 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of stem cell population maintenance. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>Q9Y5V0|ZNF706
     1  MARGQQKIQS QQKNAKKQAG QKKKQGHDQK AAAKAALIYT CTVCRTQMPD PKTFKQHFES
    61  KHPKTPLPPE LADVQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF706 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 257 nTPM

Expression across tissuesHPA

Tissue

pancreas: 257 nTPM
skin: 174 nTPM
esophagus: 142 nTPM
hippocampal formation: 116 nTPM
spinal cord: 114 nTPM
testis: 114 nTPM

Single-cell type

late spermatids: 1,689 nCPM
esophageal apical cells: 836 nCPM
esophageal suprabasal cells: 830 nCPM
early spermatids: 571 nCPM
esophageal basal cells: 472 nCPM
suprabasal keratinocytes: 464 nCPM

Immune cell

plasmacytoid DC: 535 nTPM
non-classical monocyte: 495 nTPM
intermediate monocyte: 465 nTPM
memory B-cell: 402 nTPM
naive B-cell: 346 nTPM
T-reg: 304 nTPM

Brain region

cerebellum: 126 nTPM
hippocampal formation: 123 nTPM
cerebral cortex: 122 nTPM
amygdala: 120 nTPM
basal ganglia: 118 nTPM
white matter: 115 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.7
gnomAD missense Z: 1.76
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small EDRK-rich factor-like, N-terminal
Zinc finger C2H2-type
Small EDRK-rich factor 1/2-like, N-terminal
Zinc-finger of C2H2 type
ZNF706/At2g23090 superfamily
Zinc finger protein MBS1/2-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF706 as an antibody target. Whether an autoantibody or antibody against ZNF706 could matter depends on whether native ZNF706 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF706 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF706 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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