Seroatlas · Human Serome Atlas

ZNF704

Zinc finger protein 704

Also known as: FLJ16218, Gig1, ZN704_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNC4
Gene: ZNF704
Ensembl: ENSG00000164684
Chromosome: 8
Canonical length: 412 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q6ZNC4|ZNF704
     1  MTFTFQSEDL KRDCGKKMSH QHVFSLAMEE DVKTADTKKA SRILDHEKEN TRSICLLEQK
    61  RKVVSSNIDV PPARKSSEEL DMDKVTAAMV LTSLSTSPLV RSPPVRPNES LSGSWKEGGC
   121  VPSSTSSSGY WSWSAPSDQS NPSTPSPPLS ADSFKPFRSP AQPDDGIDEA EASNLLFDEP
   181  IPRKRKNSMK VMFKCLWKNC GKVLSTAAGI QKHIRTIHLG RVGDSDYSDG EEDFYYTEIK
   241  LNTDSVADGL SSLAPVSPSQ SLASPPTFPI PDSSRTETPC AKTETKLMTP LSRSAPTTLY
   301  LVHTDHAYQA TPPVTIPGSA KFTPNGSSFS ISWQSPPVTF TGIPVSPTHH PVGTGEQRQH
   361  AHTVLSSPPR GTVSLRKPRG EGKKCRKVYG MENRDMWCTA CRWKKACQRF LD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF704 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 16 nTPM
cervix: 14 nTPM
ovary: 13 nTPM
cerebellum: 13 nTPM
endometrium: 12 nTPM
pancreas: 12 nTPM

Single-cell type

oligodendrocyte progenitor cells: 471 nCPM
renal connecting tubule cells: 467 nCPM
bergmann glia: 428 nCPM
mast cells: 424 nCPM
oligodendrocytes: 422 nCPM
distal convoluted tubule cells: 407 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 39 nTPM
white matter: 30 nTPM
basal ganglia: 23 nTPM
midbrain: 22 nTPM
thalamus: 21 nTPM
medulla oblongata: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.01
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF704 as an antibody target. Whether an autoantibody or antibody against ZNF704 could matter depends on whether native ZNF704 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF704 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF704 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...