Seroatlas · Human Serome Atlas

ZNF701

Zinc finger protein 701

Also known as: FLJ10891, ZN701_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV72
Gene: ZNF701
Ensembl: ENSG00000167562
Chromosome: 19
Canonical length: 531 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

531 residues, UniProt reviewed canonical sequence.

>Q9NV72|ZNF701
     1  MGFLHVGQDG LELPTSGDPP ASASQSAGIT GVSHRTQPPC FEGLTSKDLV REEKTRKRKR
    61  KAKESGMALL QGLLTFRDVA IEFSQEEWKC LDPAQRTLYR DVMLENYRNL VSLDTSSKCM
   121  MKMFSSTGQG NTEVVHTGTL QIHASHHIGD TCFQEIEKDI HDFVFQWQEN ETNGHEALMT
   181  KTKKLMSSTE RHDQRHAGNK PIKNELGSSF HSHLPEVHIF HPEGKIGNQV EKAINDAFSV
   241  SASQRISCRP KTRISNKYRN NFLQSSLLTQ KREVHTREKS FQRNESGKAF NGSSLLKKHQ
   301  IIHLGDKQYK CDVCGKDFHQ KRYLACHRCH TGENPYTCNE CGKTFSHNSA LLVHKAIHTG
   361  EKPYKCNECG KVFNQQSNLA RHHRVHTGEK PYKCEECDKV FSRKSHLERH RRIHTGEKPY
   421  KCKVCDKAFR RDSHLAQHTV IHTGEKPYKC NECGKTFVQN SSLVMHKVIH TGEKRYKCNE
   481  CGKVFNHKSN LACHRRLHTG EKPYKCNECG KVFNRKSNLE RHHRLHTGKK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF701 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 6.8 nTPM

Expression across tissuesHPA

Tissue

thymus: 6.8 nTPM
placenta: 5.8 nTPM
thyroid gland: 5.5 nTPM
lymph node: 5.4 nTPM
breast: 5.3 nTPM
bone marrow: 5.1 nTPM

Single-cell type

syncytiotrophoblasts: 44 nCPM
enterocytes: 33 nCPM
distal convoluted tubule cells: 33 nCPM
loop of henle epithelial cells: 33 nCPM
renal collecting duct intercalated cells: 32 nCPM
renal connecting tubule cells: 30 nCPM

Immune cell

neutrophil: 21 nTPM
basophil: 21 nTPM
eosinophil: 17 nTPM
NK-cell: 12 nTPM
intermediate monocyte: 8.9 nTPM
memory B-cell: 8.6 nTPM

Brain region

white matter: 14 nTPM
cerebellum: 12 nTPM
basal ganglia: 12 nTPM
pons: 10 nTPM
choroid plexus: 10 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -1.1
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF701 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF701 as an antibody target. Whether an autoantibody or antibody against ZNF701 could matter depends on whether native ZNF701 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF701 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF701 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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