Seroatlas · Human Serome Atlas

ZNF700

Zinc finger protein 700

Also known as: DKFZp434I1610, ZN700_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0M5
Gene: ZNF700
Ensembl: ENSG00000196757
Chromosome: 19
Canonical length: 742 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

742 residues, UniProt reviewed canonical sequence.

>Q9H0M5|ZNF700
     1  MPCCSHRSCR EDPGTSESRE MDPVAFEDVA VNFTQEEWTL LDISQKNLFR EVMLETFRNL
    61  TSIGKKWSDQ NIEYEYQNPR RSFRSLIEEK VNEIKEDSHC GETFTQVPDD RLNFQEKKAS
   121  PEVKSCDSFV CAEVGIGNSS FNMSIRGDTG HKAYEYQEYG PKPYKCQQPK NKKAFRYRPS
   181  IRTQERDHTG EKPYACKVCG KTFIFHSSIR RHMVMHSGDG TYKCKFCGKA FHSFSLYLIH
   241  ERTHTGEKPY ECKQCGKSFT YSATLQIHER THTGEKPYEC SKCDKAFHSS SSYHRHERSH
   301  MGEKPYQCKE CGKAFAYTSS LRRHERTHSG KKPYECKQYG EGLSYLISFQ THIRMNSGER
   361  PYKCKICGKG FYSAKSFQTH EKTHTGEKRY KCKQCGKAFN LSSSFRYHER IHTGEKPYEC
   421  KQCGKAFRSA SQLRVHGGTH TGEKPYECKE CGKAFRSTSH LRVHGRTHTG EKPYECKECG
   481  KAFRYVKHLQ IHERTEKHIR MPSGERPYKC SICEKGFYSA KSFQTHEKTH TGEKPYECNQ
   541  CGKAFRCCNS LRYHERTHTG EKPYECKQCG KAFRSASHLR MHERTHTGEK PYECKQCGKA
   601  FSCASNLRKH GRTHTGEKPY ECKQCGKAFR SASNLQMHER THTGEKPYEC KECEKAFCKF
   661  SSFQIHERKH RGEKPYECKH CGNGFTSAKI LQIHARTHIG EKHYECKECG KAFNYFSSLH
   721  IHARTHMGEK PYECKDCGKA FS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF700 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

spleen: 23 nTPM
liver: 21 nTPM
pancreas: 18 nTPM
small intestine: 17 nTPM
kidney: 17 nTPM
bone marrow: 16 nTPM

Single-cell type

cardiomyocytes: 2.9 nCPM
platelets: 2.8 nCPM
lacrimal acinar cells: 2.7 nCPM
gastric chief cells: 2.2 nCPM
innate lymphoid cells: 2.1 nCPM
basal prostatic cells: 1.8 nCPM

Immune cell

basophil: 4.7 nTPM
eosinophil: 4.7 nTPM
non-classical monocyte: 4.4 nTPM
memory CD8 T-cell: 4 nTPM
MAIT T-cell: 3.7 nTPM
neutrophil: 3.7 nTPM

Brain region

cerebellum: 11 nTPM
choroid plexus: 9.6 nTPM
white matter: 9.4 nTPM
thalamus: 9.2 nTPM
pons: 9 nTPM
medulla oblongata: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: -1.12
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF700 as an antibody target. Whether an autoantibody or antibody against ZNF700 could matter depends on whether native ZNF700 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF700 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF700 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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