Seroatlas · Human Serome Atlas

ZNF7

Zinc finger protein 7

Also known as: HF.16, KOX4, ZNF7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17097
Gene: ZNF7
Ensembl: ENSG00000147789
Chromosome: 8
Canonical length: 686 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>P17097|ZNF7
     1  MEVVTFGDVA VHFSREEWQC LDPGQRALYR EVMLENHSSV AGLAGFLVFK PELISRLEQG
    61  EEPWVLDLQG AEGTEAPRTS KTDSTIRTEN EQACEDMDIL KSESYGTVVR ISPQDFPQNP
   121  GFGDVSDSEV WLDSHLGSPG LKVTGFTFQN NCLNEETVVP KTFTKDAPQG CKELGSSGLD
   181  CQPLESQGES AEGMSQRCEE CGKGIRATSD IALHWEINTQ KISRCQECQK KLSDCLQGKH
   241  TNNCHGEKPY ECAECGKVFR LCSQLNQHQR IHTGEKPFKC TECGKAFRLS SKLIQHQRIH
   301  TGEKPYRCEE CGKAFGQSSS LIHHQRIHTG ERPYGCRECG KAFSQQSQLV RHQRTHTGER
   361  PYPCKECGKA FSQSSTLAQH QRMHTGEKAQ ILKASDSPSL VAHQRIHAVE KPFKCDECGK
   421  AFRWISRLSQ HQLIHTGEKP YKCNKCTKAF GCSSRLIRHQ RTHTGEKPFK CDECGKGFVQ
   481  GSHLIQHQRI HTGEKPYVCN DCGKAFSQSS SLIYHQRIHK GEKPYECLQC GKAFSMSTQL
   541  TIHQRVHTGE RPYKCNECGK AFSQNSTLFQ HQIIHAGVKP YECSECGKAF SRSSYLIEHQ
   601  RIHTRAQWFY EYGNALEGST FVSRKKVNTI KKLHQCEDCE KIFRWRSHLI IHQRIHTGEK
   661  PYKCNDCGKA FNRSSRLTQH QKIHMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 31 nTPM
skeletal muscle: 22 nTPM
spleen: 21 nTPM
skin: 20 nTPM
cervix: 19 nTPM
prostate: 19 nTPM

Single-cell type

myonuclei: 54 nCPM
late primary spermatocytes: 47 nCPM
adipocytes: 39 nCPM
fibro-adipogenic progenitors: 38 nCPM
retinal horizontal cells: 36 nCPM
cardiomyocytes: 35 nCPM

Immune cell

basophil: 29 nTPM
naive CD4 T-cell: 17 nTPM
non-classical monocyte: 16 nTPM
memory B-cell: 15 nTPM
NK-cell: 14 nTPM
T-reg: 14 nTPM

Brain region

cerebellum: 39 nTPM
white matter: 28 nTPM
cerebral cortex: 27 nTPM
pons: 24 nTPM
thalamus: 24 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 21% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF7 as an antibody target. Whether an autoantibody or antibody against ZNF7 could matter depends on whether native ZNF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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