ZNF699

Protein identityUniProt · HPA

UniProt accession

Q32M78

Gene

ZNF699

Ensembl

ENSG00000196110

Chromosome

19

Canonical length

642 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>Q32M78|ZNF699
     1  MEEERKTAEL QKNRIQDSVV FEDVAVDFTQ EEWALLDLAQ RNLYRDVMLE NFQNLASLGY
    61  PLHTPHLISQ WEQEEDLQTV KRELIQGIFM GEHREGFETQ LKTNESVASQ DICGEKISNE
   121  QKIVRFKRND SWFSSLHENQ ESCGIDYQNK SHERHLRNHM VENIYECYEE NQDGQTFSQV
   181  PNLDSLKRNT EVKSCECHEC GKAFVDHSSL KSHIRSHTGS KPYQCKECGK AFHFLACFKK
   241  HMKTPTEEKP YECKECTKAF SCSSFFRAHM KIHIGKTNYE CKECGKGFSC SSSLTEHKRI
   301  HSGDKPYECK ECGKAFSCSS SLSKHKRIHS GDKPYECKEC GKAFSSSSHL IIHIRIHTGE
   361  KPYECKECGK AFSESSKLTV HGRTHTGEKP YKCKECGKAY NCPSSLSIHM RKHTGEKPYE
   421  CLECGKAFYL PTSLNTHVKN QSREKPYECK ECGKAFSCPS SFRAHVRDHT GKIQYECKEC
   481  GKTFSRSSSL TEHLRTHSGE KPYECKECGK AFISSSHLTV HIRTHTGEKP YECKKCGKAF
   541  IYPSALRIHM RTHTGEKPYE CKECGKAFRH SSYLTVHARM HTGEKPFECL ECGKAFSCPS
   601  SFRRHVRSHT GEKPYECKEC GKAFVCPAYF RRHVKTHTRE NI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF699 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

3.1 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF699.

Disease | AllUniProt

Conditions ZNF699 is implicated in, by any mechanism.

• DEGCAGS syndrome (DEGCAGS) MIM:619488

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• DEGCAGS syndrome
• ZNF699-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.87

gnomAD pLI

0

gnomAD missense Z

0.85

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box

KeywordsUniProt

• Deafness
• DNA-binding
• Intellectual disability
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF699 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28