Seroatlas · Human Serome Atlas

ZNF697

Zinc finger protein 697

Also known as: MGC45731, ZN697_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TEC3
Gene: ZNF697
Ensembl: ENSG00000143067
Chromosome: 1
Canonical length: 545 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q5TEC3|ZNF697
     1  MKQEDNQGVC AHQDSEDKGM GSDFEDSEDR EGDPEEREMG SNPHDTNKRE GHPEPEMGSN
    61  PQDSRHREAV PDICTEGQLS EEEGVSVRGE EDDQSGVADM AMFPGLSESD SISRSLREDD
   121  DESAGENRLE EEEEQPAPPV LPWRRHLSLG SRHRGDKPAH RRFHRLHHPM AVDLGELDSL
   181  VASIMDAPTI CPDCGESFSP GAAFLQHQRI HRLAEAAAAA SLEPFGLAGE CDAMVGMMGV
   241  GVAGGFGAGP PLARPPREKP FRCGECGKGF SRNTYLTNHL RLHTGERPNL CADCGKSFSW
   301  RADLLKHRRL HTGEKPYPCP ECGEAFSLSS HLLSHRRAHA AASGAGAAAL RPFACGECGK
   361  GFVRRSHLAN HQRIHTGEKP HGCGECGKRF SWRSDLVKHQ RVHTGEKPYM CSECGETFSV
   421  SSHLFTHKRT HSGERPYVCR ECGKGFGRNS HLVNHLRVHT GEKPFRCGQC EKRFSDFSTL
   481  TQHQRTHTGE KPYTCIECGK SFIQSSHLIR HRRIHTGNKP HKCAGCGKGF RYKTHLAQHQ
   541  KLHLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF697 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

kidney: 7 nTPM
placenta: 6.5 nTPM
salivary gland: 5.1 nTPM
parathyroid gland: 4.6 nTPM
heart muscle: 4 nTPM
prostate: 4 nTPM

Single-cell type

proximal tubule cells: 62 nCPM
syncytiotrophoblasts: 48 nCPM
somatotrophs: 45 nCPM
monocytes: 42 nCPM
distal convoluted tubule cells: 27 nCPM
prostatic glandular cells: 25 nCPM

Immune cell

classical monocyte: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 18 nTPM
amygdala: 11 nTPM
white matter: 10 nTPM
basal ganglia: 9.2 nTPM
hippocampal formation: 8.6 nTPM
pons: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF697 as an antibody target. Whether an autoantibody or antibody against ZNF697 could matter depends on whether native ZNF697 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF697 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF697 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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