Seroatlas · Human Serome Atlas

ZNF695

Zinc finger protein 695

Also known as: SBZF3, ZN695_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IW36
Gene: ZNF695
Ensembl: ENSG00000197472
Chromosome: 1
Canonical length: 515 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q8IW36|ZNF695
     1  MGLLAFRDVA LEFSPEEWEC LDPAQRSLYR DVMLENYRNL ISLGEDSFNM QFLFHSLAMS
    61  KPELIICLEA RKEPWNVNTE KTARHSVLSS YLTEDILPEQ GLQVSFQKVM LRRYERCCLE
   121  KLRLRNDWEI VGEWKGQKAS YNGLDLCSAT THSKNFQCNK CVKGFSKFAN LNKCKISHTG
   181  EKPFKCKECG NVSCMSLIMT QQQRIHIGEN PYQCKKCGKA FNECSCFTDC KRIHVGEKHC
   241  KCEECNNIFK SCSSLAVVEK NHTEKKTYRC EECGKAFNLC SVLTKHKKIH TGEKPYKCEE
   301  CGKSFKLFPY LTQHKRIHSR EKPYKCEECG KVFKLLSYLT QHRRIHTGEK TFRCEECGKA
   361  FNQSSHLTEH RRIHTGEKPY KCEECGKAFT WFSYLIQHKR IHTGQKPYKC EECGKAFTWF
   421  SYLTQHKRIH TGEKPYKCDE CGKAFNWFSY LTNHKRIHTG EKPYKCEECG KAFGQSSHLS
   481  KHKTIHTREK PYKCEECGKA FNHSAQLAVH EKTHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF695 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.8 nTPM
small intestine: 0.5 nTPM
testis: 0.5 nTPM
rectum: 0.4 nTPM
breast: 0.3 nTPM
pancreas: 0.3 nTPM

Single-cell type

oocytes: 4.6 nCPM
epididymal clear cells: 2 nCPM
erythrocyte progenitors: 1.6 nCPM
late primary spermatocytes: 1.1 nCPM
kupffer cells: 1 nCPM
megakaryocyte progenitors: 0.7 nCPM

Immune cell

neutrophil: 0.7 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 2.7 nTPM
hippocampal formation: 2.6 nTPM
white matter: 2.3 nTPM
amygdala: 2.2 nTPM
basal ganglia: 2 nTPM
cerebellum: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF695 as an antibody target. Whether an autoantibody or antibody against ZNF695 could matter depends on whether native ZNF695 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF695 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF695 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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