Seroatlas · Human Serome Atlas

ZNF691

Zinc finger protein 691

Also known as: Zfp691, ZN691_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VV52
Gene: ZNF691
Ensembl: ENSG00000164011
Chromosome: 1
Canonical length: 315 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q5VV52|ZNF691
     1  MSLCSPTHSA EMSLFLQGPE EMLPLSSEGS EMGSEKEQSP EPHLPEEGEG GKPWRVDDSE
    61  GSWIPPGEKE HGQESLSDEL QETHPKKPWQ KVTVRARELG DPIAHPRHEA DEKPFICAQC
   121  GKTFNNTSNL RTHQRIHTGE KPYKCSECGK SFSRSSNRIR HERIHLEEKH YKCPKCQESF
   181  RRRSDLTTHQ QDHLGKRPYR CDICGKSFSQ SATLAVHHRT HLEPAPYICC ECGKSFSNSS
   241  SFGVHHRTHT GERPYECTEC GRTFSDISNF GAHQRTHRGE KPYRCTVCGK HFSRSSNLIR
   301  HQKTHLGEQA GKDSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF691 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

liver: 18 nTPM
thymus: 14 nTPM
epididymis: 14 nTPM
choroid plexus: 13 nTPM
ovary: 13 nTPM
parathyroid gland: 13 nTPM

Single-cell type

microglia: 24 nCPM
late primary spermatocytes: 15 nCPM
adrenal cortex cells: 14 nCPM
hepatic stellate cells: 13 nCPM
cone photoreceptor cells: 12 nCPM
tuft cells: 12 nCPM

Immune cell

basophil: 25 nTPM
naive B-cell: 24 nTPM
T-reg: 23 nTPM
NK-cell: 22 nTPM
eosinophil: 19 nTPM
memory CD8 T-cell: 18 nTPM

Brain region

white matter: 13 nTPM
medulla oblongata: 12 nTPM
thalamus: 12 nTPM
basal ganglia: 11 nTPM
pons: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.82
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF691 as an antibody target. Whether an autoantibody or antibody against ZNF691 could matter depends on whether native ZNF691 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF691 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF691 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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