Seroatlas · Human Serome Atlas

ZNF69

Zinc finger protein 69

Also known as: Cos5, ZNF69_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UC07
Gene: ZNF69
Ensembl: ENSG00000198429
Chromosome: 19
Canonical length: 566 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q9UC07|ZNF69
     1  MPCCSHRRCR EDPGTSESQE MDPVAFDDVA VNFTQEEWAL LDISQRKLYK EVMLETFRNL
    61  TSVGKSWKDQ NIEYEYQNPR RNFRSLIEKK VNEIKDDSHC GETFTQVPDD RLNFQEKKAS
   121  PEIKSCDSFV CGEVGLGNSS FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK KAFRYHPSFR
   181  TPQRDHTGEK PYACKECGKT FISHSSIQRH VVMHSGDGPY KCKFCGKAFH CLSLYLIHER
   241  IHTGEKPYEC KQCGKSFSYS ATLRIHERTH TGEKPYECQQ CGKAFHSPRC YRRHERIHTG
   301  EKAYQCKECG KAFTCPQYVR IHERTHSRKK PYECTQCGKA LSSLTSFQTH IRMHSGERPY
   361  ECKICGKGFC SANSFQRHEK THSGEKPYKC KQCGKAFIHS SSLRYHERIH TGEKPYECKQ
   421  CGKAFRSSSH LQLHGRTHTG EKPYECQECG KAFRSMKNLQ SHERTQTHVR IHSGERPYKC
   481  KLCGKGFYCP KSLQRHEKTH TGEKLYECKQ CGEAFSSSSS FRYHERTHTG EKPYKCKQCG
   541  KAFRAASVLR MHGRTHPEDK PYECKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 14 nTPM
kidney: 9 nTPM
liver: 8.4 nTPM
stomach: 8.4 nTPM
rectum: 7.5 nTPM
colon: 7.3 nTPM

Single-cell type

proximal tubule cells: 164 nCPM
sertoli cells: 115 nCPM
loop of henle epithelial cells: 113 nCPM
cholangiocytes: 91 nCPM
choroid plexus epithelial cells: 88 nCPM
megakaryocyte-erythroid progenitors: 83 nCPM

Immune cell

basophil: 13 nTPM
naive CD8 T-cell: 3.3 nTPM
naive CD4 T-cell: 3.2 nTPM
NK-cell: 2.5 nTPM
gdT-cell: 1.7 nTPM
MAIT T-cell: 1.7 nTPM

Brain region

choroid plexus: 23 nTPM
medulla oblongata: 13 nTPM
midbrain: 12 nTPM
pons: 12 nTPM
hippocampal formation: 11 nTPM
hypothalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.39
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF69 as an antibody target. Whether an autoantibody or antibody against ZNF69 could matter depends on whether native ZNF69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF69 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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