Seroatlas · Human Serome Atlas

ZNF689

Zinc finger protein 689

Also known as: FLJ90415, TIPUH1, ZN689_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CS4
Gene: ZNF689
Ensembl: ENSG00000156853
Chromosome: 16
Canonical length: 500 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Enables histone binding activity. Involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q96CS4|ZNF689
     1  MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ RALYRDVMRE
    61  TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR GLTVQRKSRT RKKNGEKEVF
   121  PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI CPDCGCTFPD HQALESHKCA QNLKKPYPCP
   181  DCGRRFSYPS LLVSHRRAHS GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR
   241  CFRRSRSLAN HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ
   301  RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC EARFSQRSTL
   361  LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL HACDDCGRRF AYPSLLASHR
   421  RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK
   481  APNCSPRSAI GGSSQRGNAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF689 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
breast: 9.6 nTPM
parathyroid gland: 6.6 nTPM
bone marrow: 6.3 nTPM
thymus: 5.5 nTPM
endometrium: 5.1 nTPM

Single-cell type

late primary spermatocytes: 152 nCPM
late spermatids: 83 nCPM
breast hormone-responsive cells: 55 nCPM
oocytes: 46 nCPM
early spermatids: 45 nCPM
platelets: 23 nCPM

Immune cell

non-classical monocyte: 10 nTPM
intermediate monocyte: 9.3 nTPM
myeloid DC: 8.9 nTPM
NK-cell: 8.8 nTPM
classical monocyte: 6.2 nTPM
gdT-cell: 5.1 nTPM

Brain region

cerebral cortex: 6.8 nTPM
white matter: 6.6 nTPM
basal ganglia: 6.4 nTPM
amygdala: 6.3 nTPM
medulla oblongata: 6.3 nTPM
thalamus: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.42
gnomAD missense Z: 2.52
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF689 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF689 as an antibody target. Whether an autoantibody or antibody against ZNF689 could matter depends on whether native ZNF689 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF689 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF689 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...