ZNF684

Protein identityUniProt · HPA

UniProt accession

Q5T5D7

Gene

ZNF684

Ensembl

ENSG00000117010

Chromosome

1

Canonical length

378 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within innate immune response and negative regulation of single stranded viral RNA replication via double stranded DNA intermediate. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q5T5D7|ZNF684
     1  MISFQESVTF QDVAVDFTAE EWQLLDCAER TLYWDVMLEN YRNLISVGCP ITKTKVILKV
    61  EQGQEPWMVE GANPHESSPE SDYPLVDEPG KHRESKDNFL KSVLLTFNKI LTMERIHHYN
   121  MSTSLNPMRK KSYKSFEKCL PPNLDLLKYN RSYTVENAYE CSECGKAFKK KFHFIRHEKN
   181  HTRKKPFECN DCGKAYSRKA HLATHQKIHN GERPFVCNDC GKAFMHKAQL VVHQRLHTGE
   241  KPYECSQCGK TFTWNSSFNQ HVKSHTLEKS FECKECGKTF RYSSSLYKHS RFHTGEKPYQ
   301  CIICGKAFGN TSVLVTHQRI HTGEKPYSCI ECGKAFIKKS HLLRHQITHT GEKPYECNRC
   361  GKAFSQKSNL IVHQKIHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF684 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0

gnomAD missense Z

0.65

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger protein, C2H2-type
• Zinc finger, C2H2 type
• KRAB box

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF684 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28