ZNF683
Tissue-resident T-cell transcription regulator protein ZNF683
Also known as: Hobit, MGC33414, ZN683_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IZ20
- Gene
- ZNF683
- Ensembl
- ENSG00000176083
- Chromosome
- 1
- Canonical length
- 524 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in T cell receptor signaling pathway; cellular response to ionomycin; and regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
524 residues, UniProt reviewed canonical sequence.
>Q8IZ20|ZNF683
1 MKEESAAQLG CCHRPMALGG TGGSLSPSLD FQLFRGDQVF SACRPLPDMV DAHGPSCASW
61 LCPLPLAPGR SALLACLQDL DLNLCTPQPA PLGTDLQGLQ EDALSMKHEP PGLQASSTDD
121 KKFTVKYPQN KDKLGKQPER AGEGAPCPAF SSHNSSSPPP LQNRKSPSPL AFCPCPPVNS
181 ISKELPFLLH AFYPGYPLLL PPPHLFTYGA LPSDQCPHLL MLPQDPSYPT MAMPSLLMMV
241 NELGHPSARW ETLLPYPGAF QASGQALPSQ ARNPGAGAAP TDSPGLERGG MASPAKRVPL
301 SSQTGTAALP YPLKKKNGKI LYECNICGKS FGQLSNLKVH LRVHSGERPF QCALCQKSFT
361 QLAHLQKHHL VHTGERPHKC SIPWVPGRNH WKSFQAWRER EVCHKRFSSS SNLKTHLRLH
421 SGARPFQCSV CRSRFTQHIH LKLHHRLHAP QPCGLVHTQL PLASLACLAQ WHQGALDLMA
481 VASEKHMGYD IDEVKVSSTS QGKARAVSLS SAGTPLVMGQ DQNNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF683 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 77 nTPM
Expression across tissuesHPA
Tissue
- testis: 77 nTPM
- salivary gland: 9.6 nTPM
- lung: 4.4 nTPM
- stomach: 3.2 nTPM
- thymus: 2.7 nTPM
- spleen: 2.1 nTPM
Single-cell type
- early spermatids: 640 nCPM
- late spermatids: 639 nCPM
- late primary spermatocytes: 55 nCPM
- t-cells: 30 nCPM
- nk-cells: 15 nCPM
- sertoli cells: 3.1 nCPM
Immune cell
- gdT-cell: 173 nTPM
- memory CD8 T-cell: 113 nTPM
- naive CD8 T-cell: 63 nTPM
- memory CD4 T-cell: 36 nTPM
- total PBMC: 24 nTPM
- naive CD4 T-cell: 13 nTPM
Brain region
- medulla oblongata: 2.4 nTPM
- cerebral cortex: 1.7 nTPM
- white matter: 1.6 nTPM
- thalamus: 1.4 nTPM
- pons: 1.2 nTPM
- spinal cord: 1.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.34
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adaptive immune response
- cellular response to ionomycin
- innate immune response
- negative regulation of transcription by RNA polymerase II
- negative regulation of type II interferon production
- positive regulation of gene expression
- regulation of extrathymic T cell differentiation
- regulation of gene expression
- regulation of natural killer cell differentiation
- regulation of NK T cell differentiation
- regulation of transcription by RNA polymerase II
- T cell receptor signaling pathway
- regulation of natural killer cell differentiation involved in immune response
Molecular functions
- DNA-binding transcription factor activity
- promoter-specific chromatin binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF683 as an antibody target. Whether an autoantibody or antibody against ZNF683 could matter depends on whether native ZNF683 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF683 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF683 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...