Seroatlas · Human Serome Atlas

ZNF681

Zinc finger protein 681

Also known as: FLJ31526, ZN681_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N22
Gene: ZNF681
Ensembl: ENSG00000196172
Chromosome: 19
Canonical length: 645 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a protein containing the krueppel associated box (KRAB) and zinc-finger domains, which may be involved in transcriptional regulation. Non-functional alleles of this gene are present in alternate genome assemblies including T2T-CHM13v1.1, resulting from a 'TG' deletion (rs61397759) which causes a frameshift and a premature stop codon. [provided by RefSeq, Sep 2022]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q96N22|ZNF681
     1  MEPLKFRDVA IEFSLEEWQC LDTIQQNLYR NVMLENYRNL VFLGIVVSKP DLITCLEQEK
    61  EPWTRKRHRM VAEPPVICSH FAQDFSPEQN IKDSFQKVTP RRYGKCEHEN LQLSKSVDEC
   121  KVQKGGYNGL NQCLPTTQSK IFQCDKYMKI FHKFSNLNGH KVRHTRKKPF KYKEFGKSFC
   181  IFSNLTQHKI ICTRVNFYKC EDCGKAFNGS SIFTKHKRIH IGEKSYICEE CGKACNQFTN
   241  LTTHKIIYTR DKLYKREECS KAFNLSSHIT THTIIHTGEN PYKREECDKA FNQSLTLTTH
   301  KIIHTREKLN EYKECGKAFN QSSHLTRHKI IHTGEKPYKC EECGKAFNQS SHLTRHKIIH
   361  TGEKPYRCEE CGKAFRQSSH LTTHKIIHTG EKPYKCEECG KAFNKSSHLT RHKSIHTGEK
   421  PYQCEKCGKA SNQSSNLTEH KNIHTEEKPY KCEECGKAFN QFSNLTTHKR IHTGEKPYKC
   481  EECGKAFNQS SILTTHKRIH TGEKSYKCEE CGKAFYRSSK LTEHKKIHTG EKPYTCEECG
   541  KAFNHSSHLA THKVIHTGEK PYQCEECGKA FNQSSHLTRH KRIHTGEKPY QCEKCGKAFN
   601  QSSNLTGHKK IHTGEKLYKP KRCNSDFENT SKFSKHKRNY AGEKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF681 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 3.6 nTPM
lymph node: 2.6 nTPM
testis: 2.3 nTPM
cerebral cortex: 2.2 nTPM
ovary: 2.1 nTPM
skin: 2.1 nTPM

Single-cell type

esophageal apical cells: 37 nCPM
early primary spermatocytes: 21 nCPM
oocytes: 18 nCPM
differentiating spermatogonia: 15 nCPM
conjunctival goblet cells: 14 nCPM
thymocytes: 14 nCPM

Immune cell

naive CD4 T-cell: 3.6 nTPM
naive CD8 T-cell: 3.2 nTPM
naive B-cell: 2.1 nTPM
T-reg: 2 nTPM
memory CD4 T-cell: 1.8 nTPM
MAIT T-cell: 1.6 nTPM

Brain region

cerebellum: 7.2 nTPM
cerebral cortex: 4.7 nTPM
hypothalamus: 4.5 nTPM
midbrain: 4.3 nTPM
pons: 4.3 nTPM
thalamus: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.87
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF681 as an antibody target. Whether an autoantibody or antibody against ZNF681 could matter depends on whether native ZNF681 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF681 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF681 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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