Seroatlas · Human Serome Atlas

ZNF680

Zinc finger protein 680

Also known as: FLJ90430, ZN680_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEM1
Gene
ZNF680
Ensembl
ENSG00000173041
Chromosome
7
Canonical length
530 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q8NEM1|ZNF680
     1  MPGPPGSLEM GPLTFRDVAI EFSLEEWQCL DTAQRNLYRK VMFENYRNLV FLGIAVSKPH
    61  LITCLEQGKE PWNRKRQEMV AKPPVIYSHF TEDLWPEHSI KDSFQKVILR GYGKCGHENL
   121  QLRISCKSVD ESKVFKEGYN ELNQCLRTTQ SKIFQCDKYV KVFHKFSNSN SHKKRNTGKK
   181  VFKCKECGKS FCMLSHLTQH IRIHTRENSY KCEECGKVLN WFSELIKHKG IHMGEKPYKC
   241  EECGKAFNQS STLIKHKKIH IEEKPFKCEE CGKAFSLFSI LSKHKIIHTG DKPYKCDECH
   301  KAFNWFATLT NHKRIHTGEK PFKCEECGKD FNQFSNLTKH KKIHTGEKPY KCEECGKAFN
   361  QFANLTRHKK IHTGEKSYKC EECGKAFIQS SNLTEHMRIH TGEKPYKCEE CGKAFNGCSS
   421  LTRHKRIHTR ENTYKCEECG KGFTLFSTLT NHKVIHTGEK SYKCDECGNV FNWPATLANH
   481  KRIHAREKPY KCEECGKAFN RSSHLTRHKK IHTGEKLYKP EKCDNNFDNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF680 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 23 nTPM
  • liver: 19 nTPM
  • tongue: 14 nTPM
  • adrenal gland: 13 nTPM
  • breast: 12 nTPM
  • cerebral cortex: 12 nTPM

Single-cell type

  • myonuclei: 270 nCPM
  • cardiomyocytes: 170 nCPM
  • adipocytes: 136 nCPM
  • retinal pigment epithelial cells: 119 nCPM
  • pituicytes/fscs: 108 nCPM
  • bergmann glia: 107 nCPM

Immune cell

  • NK-cell: 4.6 nTPM
  • basophil: 2.9 nTPM
  • memory B-cell: 2.2 nTPM
  • naive CD4 T-cell: 2.2 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • naive CD8 T-cell: 2.1 nTPM

Brain region

  • cerebellum: 39 nTPM
  • cerebral cortex: 34 nTPM
  • white matter: 33 nTPM
  • midbrain: 29 nTPM
  • basal ganglia: 29 nTPM
  • thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0.42
gnomAD missense Z
0.12
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF680 as an antibody target. Whether an autoantibody or antibody against ZNF680 could matter depends on whether native ZNF680 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF680 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF680 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF680. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...