ZNF679
Zinc finger protein 679
Also known as: MGC42415, ZN679_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYX0
- Gene
- ZNF679
- Ensembl
- ENSG00000197123
- Chromosome
- 7
- Canonical length
- 411 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
411 residues, UniProt reviewed canonical sequence.
>Q8IYX0|ZNF679
1 MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS
61 KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE LGIKDSLQKV IPRRYGKSGH
121 DNLQVKTCKS MGECEVQKGG CNEVNQCLST TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG
181 KKHFKCKKYG KSFCMVSQLH QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY
241 RCEECGKAFT WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE
301 CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK PYKCKECGKA
361 FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS MHTGEKPYKC ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF679 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 1 nTPM
Expression across tissuesHPA
Tissue
- testis: 1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- early spermatids: 32 nCPM
- late primary spermatocytes: 8.2 nCPM
- late spermatids: 8.2 nCPM
- mucous neck cells: 1.6 nCPM
- gastric progenitor cells: 1.3 nCPM
- foveolar cells: 0.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0.18
- gnomAD missense Z
- -1.19
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF679 as an antibody target. Whether an autoantibody or antibody against ZNF679 could matter depends on whether native ZNF679 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF679 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF679 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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