Seroatlas · Human Serome Atlas

ZNF678

Zinc finger protein 678

Also known as: MGC42493, ZN678_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SXM1
Gene: ZNF678
Ensembl: ENSG00000181450
Chromosome: 1
Canonical length: 525 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q5SXM1|ZNF678
     1  MGTISLCIGV CAFEGANTST SFYKLVYTAI LSYSIQDLLP EQDMKDLCQK VTLTRHRSWG
    61  LDNLHLVKDW RTVNEGKGQK EYCNRLTQCS STKSKIFQCI ECGRNFSWRS ILTEHKRIHT
   121  GEKPYKCEEC GKVFNRCSNL TKHKRIHTGE KPYKCDECGK VFNWWSQLTN HKKIHTGEKP
   181  YKCDECDKVF NWWSQLTSHK KIHSGEKPYP CEECGKAFTQ FSNLTQHKRI HTGEKPYKCK
   241  ECCKAFNKFS NLTQHKRIHT GEKPYKCEEC GNVFNECSHL TRHRRIHTGE KPYKCEECGK
   301  AFTQFASLTR HKRIHTGEKP YQCEECGKTF NRCSHLSSHK RIHTGEKPYK CEECGRTFTQ
   361  FSNLTQHKRI HTGEKPYKCK ECGKAFNKFS SLTQHRRIHT GVKPYKCEEC GKVFKQCSHL
   421  TSHKRIHTGE KPYKCKECGK AFYQSSILSK HKRIHTEEKP YKCEECGKAF NQFSSLTRHK
   481  RIHTGEKRYK CKECGKGFYQ SSIHSKYKRI YTGEEPDKCK KCGSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF678 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

retina: 5.5 nTPM
thyroid gland: 5.1 nTPM
lymph node: 4.2 nTPM
thymus: 4.1 nTPM
placenta: 4 nTPM
ovary: 3.8 nTPM

Single-cell type

thyrotrophs: 69 nCPM
lactotrophs: 69 nCPM
somatotrophs: 64 nCPM
renal collecting duct intercalated cells: 62 nCPM
prostatic glandular cells: 61 nCPM
microglia: 59 nCPM

Immune cell

basophil: 5.4 nTPM
memory B-cell: 3.8 nTPM
naive B-cell: 2.7 nTPM
plasmacytoid DC: 1.8 nTPM
naive CD8 T-cell: 1.7 nTPM
T-reg: 1.7 nTPM

Brain region

white matter: 20 nTPM
hypothalamus: 18 nTPM
cerebellum: 17 nTPM
thalamus: 16 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0.02
gnomAD missense Z: -0.69

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF678 as an antibody target. Whether an autoantibody or antibody against ZNF678 could matter depends on whether native ZNF678 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF678 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF678 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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