ZNF675

Protein identityUniProt · HPA

UniProt accession

Q8TD23

Gene

ZNF675

Ensembl

ENSG00000197372

Chromosome

19

Canonical length

568 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Involved in negative regulation of osteoclast differentiation; negative regulation of signal transduction; and regulation of DNA-templated transcription. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q8TD23|ZNF675
     1  MGLLTFRDVA IEFSLEEWQC LDTAQRNLYK NVILENYRNL VFLGIAVSKQ DLITCLEQEK
    61  EPLTVKRHEM VNEPPVMCSH FAQEFWPEQN IKDSFEKVTL RRYEKCGNDN FQLKGCKSVD
   121  ECKLHKGGYN GLNQCLPTMQ SKMFQCDKYV KVFNKFSHSD RHKIKHMENK PFKCKECGRS
   181  FCMLSHLTRH ERNYTKVNFC KCEECEKAVN QSSKLTKHKR IYTCEKLYKC QECDRTFNQF
   241  SNLTEYKKDY AREKPYKCEE CGKAFNQSSH LTTHKIIHTG EKPYKCEECG KAFNQFSNLT
   301  THKKIHTGEQ PYICEECGKA FTQSSTLTTH KRIHTGEKPY KCEECGKAFN RSSKLTEHKN
   361  IHTGEQPYKC EECGKAFNRS SNLTEHRKIH TEEKPYKCKE CGKAFKHSSA LTTHKRIHTG
   421  EKPYKCEECG KAFNRSSKLT EHKKLHTGKK PYKCEECGKA FIQSSKLTEH KKIHSGEIPY
   481  KCEECGKAFK HSSSLTTHKR IHTGEKPYKC EECGKAFSRS SKLTEHKIIH TGEKPYKCER
   541  CDKAFNQSAN LTKHKKIHTG EKLQNWNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF675 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

13 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0.12

gnomAD missense Z

-0.22

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bone resorption
• negative regulation of canonical NF-kappaB signal transduction
• negative regulation of cytokine-mediated signaling pathway
• negative regulation of interleukin-1-mediated signaling pathway
• negative regulation of JNK cascade
• negative regulation of osteoclast differentiation
• negative regulation of transcription by RNA polymerase II
• negative regulation of tumor necrosis factor-mediated signaling pathway
• regulation of DNA-templated transcription

Molecular functions

• DNA binding
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• ubiquitin protein ligase binding
• zinc ion binding

Cellular components

• nucleus
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF675 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRAF6