Seroatlas · Human Serome Atlas

ZNF672

Zinc finger protein 672

Also known as: FLJ22301, ZN672_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q499Z4
Gene: ZNF672
Ensembl: ENSG00000171161
Chromosome: 1
Canonical length: 452 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q499Z4|ZNF672
     1  MFATSGAVAA GKPYSCSECG KSFCYSSVLL RHERAHGGDG RFRCLECGER CARAADLRAH
    61  RRTHAGQTLY ICSECGQSFR HSGRLDLHLG AHRQRCRTCP CRTCGRRFPH LPALLLHRRR
   121  QHLPERPRRC PLCARTFRQS ALLFHQARAH PLGTTSDPAA PPHRCAQCPR AFRSGAGLRS
   181  HARIHVSRSP TRPRVSDAHQ CGVCGKCFGK SSTLTRHLQT HSGEKPFKCP ECGKGFLESA
   241  TLVRHQRTHT GEKPYACGDC GRCFSESSTL LRHRRSHQGE RPHACATCGK GFGQRSDLVV
   301  HQRIHTGEKP FACPECGRRF SDRSDLTKHR RTHTGEKPYR CELCGKRFTC VSNLNVHRRN
   361  HAGHKPHKCP ECSKAFSVAS KLALHRKTHL GERPAECAEC GKCFSHSRSL SQHQRAHTRA
   421  RTAAAVAIQS AVGTALVFEG PAEQEKPGFS VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF672 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 47 nTPM
tongue: 33 nTPM
heart muscle: 28 nTPM
liver: 25 nTPM
prostate: 23 nTPM
kidney: 20 nTPM

Single-cell type

syncytiotrophoblasts: 93 nCPM
platelets: 49 nCPM
early primary spermatocytes: 42 nCPM
esophageal apical cells: 39 nCPM
cytotrophoblasts: 38 nCPM
epididymal clear cells: 35 nCPM

Immune cell

myeloid DC: 24 nTPM
classical monocyte: 16 nTPM
intermediate monocyte: 16 nTPM
non-classical monocyte: 16 nTPM
naive B-cell: 15 nTPM
total PBMC: 14 nTPM

Brain region

cerebellum: 34 nTPM
medulla oblongata: 34 nTPM
white matter: 30 nTPM
midbrain: 29 nTPM
thalamus: 29 nTPM
choroid plexus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.08
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF672 as an antibody target. Whether an autoantibody or antibody against ZNF672 could matter depends on whether native ZNF672 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF672 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF672 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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