Seroatlas · Human Serome Atlas

ZNF671

Zinc finger protein 671

Also known as: FLJ23506, ZN671_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAW3
Gene: ZNF671
Ensembl: ENSG00000083814
Chromosome: 19
Canonical length: 534 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q8TAW3|ZNF671
     1  MLSPVSRDAS DALQGRKCLR PRSRRLPLPA AVRAHGPMAE LTDSARGCVV FEDVFVYFSR
    61  EEWELLDDAQ RLLYHDVMLE NFALLASLGI AFSRSRAVMK LERGEEPWVY DQVDMTSATE
   121  REAQRGLRPG CWHGVEDEEV SSEQSIFVAG VSEVRTLMAE LESHPCDICG PILKDTLHLA
   181  KYHGGKARQK PYLCGACGKQ FWFSTDFDQH QNQPNGGKLF PRKEGRDSVK SCRVHVPEKT
   241  LTCGKGRRDF SATSGLLQHQ ASLSSMKPHK STKLVSGFLM GQRYHRCGEC GKAFTRKDTL
   301  ARHQRIHTGE RPYECNECGK FFSQSYDLFK HQTVHTGERP YECSECGKFF RQISGLIEHR
   361  RVHTGERLYQ CGKCGKFFSS KSNLIRHQEV HTGARPYVCS ECGKEFSRKH TLVLHQRTHT
   421  GERPYECSEC GKAFSQSSHL NVHWRIHSSD YECSRCGKAF SCISKLIQHQ KVHSGEKPYE
   481  CSKCGKAFTQ RPNLIRHWKV HTGERPYVCS ECGREFIRKQ TLVLHQRVHA GEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF671 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
spleen: 13 nTPM
thymus: 13 nTPM
pituitary gland: 9.5 nTPM
parathyroid gland: 8.9 nTPM
thyroid gland: 8 nTPM

Single-cell type

cardiomyocytes: 27 nCPM
myonuclei: 16 nCPM
hepatic stellate cells: 13 nCPM
thymocytes: 11 nCPM
thymic myoid cells: 11 nCPM
podocytes: 11 nCPM

Immune cell

naive B-cell: 31 nTPM
naive CD4 T-cell: 24 nTPM
memory B-cell: 23 nTPM
MAIT T-cell: 21 nTPM
NK-cell: 21 nTPM
naive CD8 T-cell: 20 nTPM

Brain region

cerebellum: 16 nTPM
hypothalamus: 9 nTPM
white matter: 8.2 nTPM
spinal cord: 8.1 nTPM
choroid plexus: 7.6 nTPM
basal ganglia: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF671 as an antibody target. Whether an autoantibody or antibody against ZNF671 could matter depends on whether native ZNF671 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF671 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF671 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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