ZNF669
Zinc finger protein 669
Also known as: FLJ12606, ZN669_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96BR6
- Gene
- ZNF669
- Ensembl
- ENSG00000188295
- Chromosome
- 1
- Canonical length
- 464 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
464 residues, UniProt reviewed canonical sequence.
>Q96BR6|ZNF669
1 MVSGLRLASR SGEEGWLKPA VARLGPPRHR LRNLRTESPW RSRGSVLFCS GPGRAGRAAE
61 PLHPVCTCGR HFRRPEPCRE PLASPIQDSV AFEDVAVNFT QEEWALLDSS QKNLYREVMQ
121 ETCRNLASVG SQWKDQNIED HFEKPGKDIR NHIVQRLCES KEDGQYGEVV SQIPNLDLNE
181 NISTGLKPCE CSICGKVFVR HSLLNRHILA HSGYKPYGEK QYKCEQCGKF FVSVPGVRRH
241 MIMHSGNPAY KCTICGKAFY FLNSVERHQR THTGEKPYKC KQCGKAFTVS GSCLIHERTH
301 TGEKPYECKE CGKTFRFSCS FKTHERTHTG ERPYKCTKCD KAFSCSTSLR YHGSIHTGER
361 PYECKQCGKA FSRLSSLCNH RSTHTGEKPY ECKQCDQAFS RLSSLHLHER IHTGEKPYEC
421 KKCGKAYTRS SHLTRHERSH DIEAGCSDSA YNPSTLGGQG VWIALocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF669 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 11 nTPM
- thymus: 8.2 nTPM
- tonsil: 5.2 nTPM
- breast: 5.1 nTPM
- lymph node: 5 nTPM
- ovary: 4.9 nTPM
Single-cell type
- b-cells: 21 nCPM
- innate lymphoid cells: 13 nCPM
- late primary spermatocytes: 13 nCPM
- granulosa cells: 13 nCPM
- endometrial luminal cells: 13 nCPM
- nk-cells: 12 nCPM
Immune cell
- basophil: 11 nTPM
- eosinophil: 9 nTPM
- memory B-cell: 6.4 nTPM
- T-reg: 6.2 nTPM
- naive CD4 T-cell: 5.9 nTPM
- MAIT T-cell: 5.8 nTPM
Brain region
- cerebellum: 16 nTPM
- white matter: 12 nTPM
- cerebral cortex: 10 nTPM
- basal ganglia: 10 nTPM
- hypothalamus: 10 nTPM
- pons: 9.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.67
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF669 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF669 as an antibody target. Whether an autoantibody or antibody against ZNF669 could matter depends on whether native ZNF669 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF669 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF669 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...