Seroatlas · Human Serome Atlas

ZNF668

Zinc finger protein 668

Also known as: FLJ13479, ZN668_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K58
Gene: ZNF668
Ensembl: ENSG00000167394
Chromosome: 16
Canonical length: 619 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in DNA repair. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q96K58|ZNF668
     1  MEVEAAEARS PAPGYKRSGR RYKCLSCTKT FPNAPRAARH AATHGPADCS EEVAEVKPKP
    61  ETEAKAEEAS GEKVSGSAAK PRPYACPLCP KAYKTAPELR SHGRSHTGEK PFPCPECGRR
   121  FMQPVCLRVH LASHAGELPF RCAHCPKAYG ALSKLKIHQR GHTGERPYAC ADCGKSFADP
   181  SVFRKHRRTH AGLRPYSCER CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT
   241  CHQRIHAAQK PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR
   301  AHEGVKPYHC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD LKRHALVHSG
   361  QRPFRCEECG RAFAERASLT KHSRVHSGER PFHCNACGKS FVVSSSLRKH ERTHRSSEAA
   421  GVPPAQELVV GLALPVGVAG ESSAAPAAGA GLGDPPAGLL GLPPESGGVM ATQWQVVGMT
   481  VEHVECQDAG VREAPGPLEG AGEAGGEEAD EKPPQFVCRE CKETFSTMTL LRRHERSHPE
   541  LRPFPCTQCG KSFSDRAGLR KHSRTHSSVR PYTCPHCPKA FLSASDLRKH ERTHPVPMGT
   601  PTPLEPLVAL LGMPEEGPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF668 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 7.4 nTPM
cerebellum: 7.3 nTPM
cerebral cortex: 7.1 nTPM
skin: 7 nTPM
testis: 7 nTPM
endometrium: 6.8 nTPM

Single-cell type

early spermatids: 81 nCPM
differentiating spermatogonia: 19 nCPM
late spermatids: 18 nCPM
neutrophils: 17 nCPM
extravillous trophoblasts: 17 nCPM
epicardial cells: 16 nCPM

Immune cell

gdT-cell: 11 nTPM
basophil: 8.7 nTPM
eosinophil: 8 nTPM
NK-cell: 7.8 nTPM
MAIT T-cell: 7.3 nTPM
memory CD8 T-cell: 6.7 nTPM

Brain region

cerebral cortex: 18 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
cerebellum: 13 nTPM
hippocampal formation: 13 nTPM
amygdala: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF668.

Disease | AllUniProt

Conditions ZNF668 is implicated in, by any mechanism.

Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies (NEDGEF) MIM:620194

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

marked facial dysmorphism
Profound global developmental delay
Progressive microcephaly
Failure to thrive
Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.22
gnomAD missense Z: 2.35
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF668 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HMGB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF668 as an antibody target. Whether an autoantibody or antibody against ZNF668 could matter depends on whether native ZNF668 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF668 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF668 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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