Seroatlas · Human Serome Atlas

ZNF667

Zinc finger protein 667

Also known as: FLJ14011, ZN667_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYK9
Gene: ZNF667
Ensembl: ENSG00000198046
Chromosome: 19
Canonical length: 610 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q5HYK9|ZNF667
     1  MPSARGKSKS KAPITFGDLA IYFSQEEWEW LSPIQKDLYE DVMLENYRNL VSLGLSFRRP
    61  NVITLLEKGK APWMVEPVRR RRAPDSGSKC ETKKLPPNQC NKSGQSICQK LVSAQQKAPT
   121  RKSGCNKNSV LVKPKKGHSG KKPLKCNDCG KTFSRSFSLK LHQNIHTGEK PFECSNCRKA
   181  FRQISSILLH QRIHSGKKSH ECNKCGESFN QRTTLILHMR IHDGKEILDC GKALSQCQSF
   241  NIHQKIHVVG NVCQCRKCGK AFNQMSSLLL HKKIHNGKKT HKYNKCGRGF KKKSVFVVHK
   301  RIHAGEKIPE NAKALSQSLQ QRSHHLENPF KCRKCGKLFN RISPLMLHQR IHTSEKPYKC
   361  DKCDKFFRRL STLILHLRIH NGEKLYRCNK CEKVCNRHSS LIQHQKVHTK KKKLFECKEC
   421  GKMFSGTANL KIHQNIHSEE KPFKCNKCSK VFGRQSFLIE HQRIHTGEKP YQCEECGKAF
   481  SHRISLTRHK RIHTEDRPYE CDQCGKAFSQ SAHLAQHERI HTGEKPYTCK TCGKAFSQRT
   541  SLILHERSHT GEKPYECNEC GKAFSSGSDL IRHQRSHSSE KPYECSKCGK AYSRSSSLIR
   601  HQNTHSEEKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF667 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 22 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 11 nTPM
hippocampal formation: 10 nTPM
hypothalamus: 9.9 nTPM
cerebellum: 9.4 nTPM

Single-cell type

lactotrophs: 113 nCPM
somatotrophs: 111 nCPM
other brain neurons: 48 nCPM
brain inhibitory neurons: 47 nCPM
thyrotrophs: 46 nCPM
brain excitatory neurons: 45 nCPM

Immune cell

naive B-cell: 3 nTPM
NK-cell: 2.7 nTPM
naive CD8 T-cell: 1.9 nTPM
plasmacytoid DC: 1.1 nTPM
naive CD4 T-cell: 0.8 nTPM
memory B-cell: 0.6 nTPM

Brain region

hippocampal formation: 34 nTPM
basal ganglia: 31 nTPM
cerebral cortex: 30 nTPM
hypothalamus: 29 nTPM
amygdala: 28 nTPM
white matter: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF667 as an antibody target. Whether an autoantibody or antibody against ZNF667 could matter depends on whether native ZNF667 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF667 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF667 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...