Seroatlas · Human Serome Atlas

ZNF665

Zinc finger protein 665

Also known as: FLJ14345, ZFP160L, ZN665_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H7R5
Gene
ZNF665
Ensembl
ENSG00000197497
Chromosome
19
Canonical length
678 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear membrane

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>Q9H7R5|ZNF665
     1  MALPQGQLTF KDVAIEFSQE EWTCLDPAQK TLYRDVMLEN YRNLVSLDIS CKCVNTDLPP
    61  KGKNNMGEAF YTVKLERLES CDTVGLSFQE VQKNTYDFEC QWKDDEGNYK TVLMLQKENL
   121  PGRRAQRDRR AAGNRHIENQ LGVSFQSHLP ELQQFQHEGK IYEYNQVEKS PNNRGKHYKC
   181  DECGKVFSQN SRLTSHKRIH TGEKPYQCNK CGKAFTVRSN LTIHQVIHTG EKPYKCNECG
   241  KVFSQPSNLA GHQRIHTGEK PYKCNECGKA FRAHSKLTTH QVIHTGEKPY KCKECGKCFT
   301  QNSHLASHRR IHTGEKPYKC NECGKAFSVR SSLTTHQTIH TGEKPYKCNE CGKVFRHNSY
   361  LAKHRRIHTG EKPYKCNECG KAFSMHSNLT KHQIIHTGEK PFKCNECVKV FTQYSHLANH
   421  RRIHTGEKPY RCDECGKAFS VRSSLTTHQA IHTGEKPYKC NDCGKVFTQN SHLASHRGIH
   481  SGEKPYKCDE CGKAFSQTSQ LARHWRVHTG EKPYKCNECG KAFSVHSSLT IHQTIHTGQK
   541  PYKCNDCGKV FRHNSYLAIH QRIHTGEKPY KCNECGKAFS VHSNLATHQV IHTGEKPYKC
   601  NECGKVFTQN SHLANHRRIH TGEKPYRCNE CGKAFSVRST LTTHMAVHTG DKPYKCNQCG
   661  KVFTQNSNLA KHRRIHSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF665 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
2.3 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2.3 nTPM
  • fallopian tube: 1.7 nTPM
  • parathyroid gland: 1.4 nTPM
  • thymus: 1.4 nTPM
  • thyroid gland: 1.4 nTPM
  • breast: 1.2 nTPM

Single-cell type

  • ovarian stromal cells: 17 nCPM
  • fibro-adipogenic progenitors: 16 nCPM
  • differentiating spermatogonia: 13 nCPM
  • bergmann glia: 12 nCPM
  • myosatellite cells: 12 nCPM
  • basal prostatic cells: 11 nCPM

Immune cell

  • naive B-cell: 2.1 nTPM
  • NK-cell: 2 nTPM
  • memory B-cell: 1.2 nTPM
  • memory CD8 T-cell: 0.9 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.7 nTPM

Brain region

  • cerebellum: 7.2 nTPM
  • white matter: 6.3 nTPM
  • cerebral cortex: 4.8 nTPM
  • midbrain: 4.8 nTPM
  • basal ganglia: 4.7 nTPM
  • medulla oblongata: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0.01
gnomAD missense Z
-0.76
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF665 as an antibody target. Whether an autoantibody or antibody against ZNF665 could matter depends on whether native ZNF665 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF665 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF665 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF665. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...