ZNF664
Zinc finger protein 664
Also known as: DKFZp761B128, ZFOC1, ZN664_HUMAN, ZNF176
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N3J9
- Gene
- ZNF664
- Ensembl
- ENSG00000179195
- Chromosome
- 12
- Canonical length
- 261 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
261 residues, UniProt reviewed canonical sequence.
>Q8N3J9|ZNF664
1 MIYKCPMCRE FFSERADLFM HQKIHTAEKP HKCDKCDKGF FHISELHIHW RDHTGEKVYK
61 CDDCGKDFST TTKLNRHKKI HTVEKPYKCY ECGKAFNWSS HLQIHMRVHT GEKPYVCSEC
121 GRGFSNSSNL CMHQRVHTGE KPFKCEECGK AFRHTSSLCM HQRVHTGEKP YKCYECGKAF
181 SQSSSLCIHQ RVHTGEKPYR CCGCGKAFSQ SSSLCIHQRV HTGEKPFKCD ECGKAFSQST
241 SLCIHQRVHT KERNHLKISV ILocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF664 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 130 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 130 nTPM
- parathyroid gland: 120 nTPM
- midbrain: 96 nTPM
- thyroid gland: 86 nTPM
- small intestine: 77 nTPM
- duodenum: 74 nTPM
Single-cell type
- late spermatids: 64 nCPM
- early spermatids: 36 nCPM
- tuft cells: 12 nCPM
- epicardial cells: 11 nCPM
- platelets: 9.9 nCPM
- medullary thymic epithelial cells: 7.2 nCPM
Immune cell
- MAIT T-cell: 1.5 nTPM
- T-reg: 1.5 nTPM
- gdT-cell: 1 nTPM
- naive B-cell: 1 nTPM
- naive CD4 T-cell: 0.9 nTPM
- memory CD4 T-cell: 0.8 nTPM
Brain region
- white matter: 103 nTPM
- spinal cord: 102 nTPM
- medulla oblongata: 97 nTPM
- midbrain: 96 nTPM
- basal ganglia: 96 nTPM
- cerebellum: 95 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0
- gnomAD missense Z
- 2.42
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF664 as an antibody target. Whether an autoantibody or antibody against ZNF664 could matter depends on whether native ZNF664 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF664 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF664 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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