Seroatlas · Human Serome Atlas

ZNF662

Zinc finger protein 662

Also known as: FLJ45880, ZN662_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZS27
Gene: ZNF662
Ensembl: ENSG00000182983
Chromosome: 3
Canonical length: 426 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q6ZS27|ZNF662
     1  MLENYGAVAS LAAFPFPKPA LISQLERGET PWCSVPRGAL DGEAPRGISS GYPFLKPAGI
    61  SHPEQVEEPL NLKLQGEGPS LICPEGVLKR KKEDFILKEE IIEEAQDLMV LSSGPQWCGS
   121  QELWFGKTCE EKSRLGRWPG YLNGGRMESS TNDIIEVIVK DEMISVEESS GNTDVNNLLG
   181  IHHKILNEQI FYICEECGKC FDQNEDFDQH QKTHNGEKVY GCKECGKAFS FRSHCIAHQR
   241  IHSGVKPYEC QECAKAFVWK SNLIRHQRIH TGEKPFECKE CGKGFSQNTS LTQHQRIHTG
   301  EKPYTCKECG KSFTRNPALL RHQRMHTGEK PYECKDCGKG FMWNSDLSQH QRVHTGDKPH
   361  ECTDCGKSFF CKAHLIRHQR IHTGERPYKC NDCGKAFSQN SVLIKHQRRH ARDKPYNCQI
   421  SHLLEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF662 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

ovary: 11 nTPM
retina: 10 nTPM
skin: 9.2 nTPM
cerebellum: 8.6 nTPM
cervix: 8.4 nTPM
endometrium: 7.5 nTPM

Single-cell type

oocytes: 14 nCPM
early primary spermatocytes: 8.5 nCPM
late spermatids: 5.3 nCPM
esophageal apical cells: 4.9 nCPM
late primary spermatocytes: 4.3 nCPM
hematopoietic stem cells: 3.4 nCPM

Immune cell

naive CD4 T-cell: 1.3 nTPM
naive CD8 T-cell: 1.3 nTPM
NK-cell: 0.5 nTPM
basophil: 0.4 nTPM
myeloid DC: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM

Brain region

cerebellum: 16 nTPM
choroid plexus: 13 nTPM
white matter: 13 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 9.9 nTPM
hypothalamus: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF662 as an antibody target. Whether an autoantibody or antibody against ZNF662 could matter depends on whether native ZNF662 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF662 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF662 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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