Seroatlas · Human Serome Atlas

ZNF660

Zinc finger protein 660

Also known as: FLJ36870, ZN660_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6AZW8
Gene: ZNF660
Ensembl: ENSG00000144792
Chromosome: 3
Canonical length: 331 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains multiple C2H2 zinc finger domains, and is located in a cluster of zinc-finger encoding genes on chromosome 3. Naturally-occurring readthrough transcription is observed between this gene and the downstream zinc finger protein 197 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q6AZW8|ZNF660
     1  MRRKTRNFKH KTVKDNKVLT EGSDQESEKD NSQCCDPATN ERVQAEKRQY VCTECGKAFS
    61  QSANLTVHER IHTGEKPYKC KECGKAFSHS SNLVVHRRIH TGLKPYTCSE CGKSFSGKSH
   121  LIRHQGIHSG EKTYECKECG KAFSRSSGLI SHHRVHTGEK PYSCIECGKA FSRSSNLTQH
   181  QRMHRGKKVY KCKECGKTCG SNTKIMDHQR IHTGEKPYEC DECGKTFILR KTLNEHQRLH
   241  RREKPYKCNE CGKAFTSNRN LVDHQRVHTG EKPYKCNECG KTFRQTSQVI LHLRTHTKEK
   301  PYKCSECGKA YRYSSQLIQH QRKHNEEKET S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF660 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 4.2 nTPM

Expression across tissuesHPA

Tissue

retina: 4.2 nTPM
ovary: 3.4 nTPM
cervix: 2.3 nTPM
pituitary gland: 2.3 nTPM
cerebellum: 2.2 nTPM
endometrium: 2.2 nTPM

Single-cell type

early spermatids: 3.8 nCPM
cholangiocytes: 2 nCPM
hematopoietic stem cells: 1.9 nCPM
megakaryocyte progenitors: 1.5 nCPM
müller glia: 1.5 nCPM
epididymal efferent duct absorptive cells: 1.2 nCPM

Immune cell

plasmacytoid DC: 0.9 nTPM
NK-cell: 0.4 nTPM
myeloid DC: 0.3 nTPM
naive B-cell: 0.3 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM

Brain region

cerebellum: 7.9 nTPM
medulla oblongata: 5.4 nTPM
hypothalamus: 5.2 nTPM
thalamus: 5.2 nTPM
midbrain: 5 nTPM
pons: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF660 as an antibody target. Whether an autoantibody or antibody against ZNF660 could matter depends on whether native ZNF660 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF660 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF660 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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