Seroatlas · Human Serome Atlas

ZNF66

Zinc finger protein 66

Also known as: FLJ16537, ZNF66_HUMAN, ZNF66P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN08
Gene: ZNF66
Ensembl: ENSG00000160229
Chromosome: 19
Canonical length: 573 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q6ZN08|ZNF66
     1  MGPLQFRDVA IEFSLEEWHC LDMAQRNLYR DVMLENYRNL VFLGIVVSKP DLITHLEQGK
    61  KPSTMQRHEM VANPSVLCSH FNQDLWPEQS IKDSFQKLIL RRHKKCGHDN LQLKKGCESV
   121  DKCKVHKRGY NGLNQCLTTT QSKMFQCDKH GKVFHQFSNT NRHKIRHTGK NPCKFTECGK
   181  AFNRSSTFTT HKKIHTGEKP YKCIECGKAF NRSSHLTTHK IIHTGEKRYK CEDCGKAFNR
   241  SSNLTTHKKI HTGEKPYKCE ECGKAFKRSS ILTTHKRIHT GEKPYKCEEC GKVFKYLSSL
   301  STHKIIHTGE KPYKCEECGK AFNWSSHLTT HKRIHTGEKP YKCEECGKGF KYSSTLTKHK
   361  IIHTGEKPYK CEECGEAFKY SCSLTAHKII HTGKKPYKCE ECGKVFKHSS PLSKHKRIHT
   421  GEKPYKCEEC GKAFSRSSIL TTHKIIHTGE KPYECEDCGK AFNRSSNLTK HKKIHTGEKP
   481  YKCEECGKAF KCSSILTTHK RIHTADKPYK CEECGKDFKY SSTLTRHKKI HTGGKPHKCN
   541  KCGKAFISSS NLSRHEIIHM GGNPYKCENV AKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF66 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

ovary: 6.1 nTPM
bone marrow: 5.1 nTPM
retina: 4.8 nTPM
skin: 3.4 nTPM
lymph node: 2.8 nTPM
thyroid gland: 2.8 nTPM

Single-cell type

papillary tip epithelial cells: 44 nCPM
microglia: 28 nCPM
brain inhibitory neurons: 24 nCPM
brain excitatory neurons: 23 nCPM
renal collecting duct intercalated cells: 22 nCPM
hematopoietic stem cells: 21 nCPM

Immune cell

neutrophil: 17 nTPM
basophil: 10 nTPM
naive B-cell: 3.8 nTPM
NK-cell: 3.7 nTPM
eosinophil: 3 nTPM
plasmacytoid DC: 3 nTPM

Brain region

cerebellum: 88 nTPM
cerebral cortex: 82 nTPM
white matter: 77 nTPM
amygdala: 74 nTPM
basal ganglia: 72 nTPM
pons: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0.07
gnomAD missense Z: -2.18

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF66 as an antibody target. Whether an autoantibody or antibody against ZNF66 could matter depends on whether native ZNF66 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF66 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF66 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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