Seroatlas · Human Serome Atlas

ZNF648

Zinc finger protein 648

Also known as: FLJ46813, ZN648_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T619
Gene: ZNF648
Ensembl: ENSG00000179930
Chromosome: 1
Canonical length: 568 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q5T619|ZNF648
     1  MAQVDSQDRW GEASPLSSLT EEAHDTQMLS MNLESDDEDG GEAEKEGTAD PVACPRGSSP
    61  VTHENPDLPW PHPLGKEEEK FSDSSSAGGM GQKPVEMSGK ASWSRDVTKI NETQGSPGAS
   121  RALGSLPSGL AHKLLGQMQP LGDRLPAGDD GYSGANQDAV LDVPPSFPSN GKYLCAHKSV
   181  DTSAGNSSLL CFPRPGSNWD LPTQETHTPA QASATPASLA AAVLAKARNS RKVQNQAGRR
   241  EGGEAEARPY RCLRGGRAFQ KPSKPLSPAE TRGGAAKRYA CELCGKAYSH RGTLQQHRRL
   301  HTGERPYQCS FCDKAYTWSS DHRKHIRTHT GEKPYPCPDC GKAFVRSSDL RKHQRNMHSN
   361  NKPFPCSECG LTFNKPLSLL RHQRTHLGAK PFRCPACDRE FAVASRMVEH QRVHSGERPF
   421  PCPTCGKCFT KSSNLSEHQT LHTGQRPFKC ADCGVAFAQP SRLVRHQRIH TGERPFPCTQ
   481  CGQAFARSST LKRHQQIHSG EKGFLCAECG RAFRIASELA QHIRMHNGER PYQCEDCGQA
   541  FTRSNHLQRH RAKHGTCKKE PIPSSSDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF648 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

testis: 0.5 nTPM
liver: 0.4 nTPM
ovary: 0.3 nTPM
epididymis: 0.2 nTPM
pituitary gland: 0.2 nTPM
breast: 0.1 nTPM

Single-cell type

cardiomyocytes: 7.1 nCPM
respiratory deuterosomal cells: 3.1 nCPM
undifferentiated spermatogonia: 1.9 nCPM
pituitary stem cells: 1.8 nCPM
somatotrophs: 1.7 nCPM
differentiating spermatogonia: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 3.3 nTPM
hypothalamus: 2.2 nTPM
medulla oblongata: 1.5 nTPM
midbrain: 1.4 nTPM
pons: 1.4 nTPM
choroid plexus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF648 as an antibody target. Whether an autoantibody or antibody against ZNF648 could matter depends on whether native ZNF648 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF648 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF648 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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