Seroatlas · Human Serome Atlas

ZNF641

Zinc finger protein 641

Also known as: FLJ31295, ZN641_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N77
Gene: ZNF641
Ensembl: ENSG00000167528
Chromosome: 12
Canonical length: 438 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q96N77|ZNF641
     1  MQAEDRSQFG SAAEMLSEQT AALGTGWESM NVQLDGAEPQ VERGSQEERP WRTVPGPLEH
    61  LCCDLEEEPQ SLQEKAQSAP WVPAIPQEGN TGDWEMAAAL LAAGSQGLVT IKDVSLCFSQ
   121  EEWRSLDPSQ TDFYGEYVMQ ENCGIVVSLR FPIPKLDMLS QLEGGEEQWV PDPQDLEERD
   181  ILRVTYTGDG SEHEGDTPEL EAEPPRMLSS VSEDTVLWNP EHDESWDSMP SSSRGMLLGP
   241  PFLQEDSFSN LLCSTEMDSL LRPHTCPQCG KQFVWGSHLA RHQQTHTGER PYSCLKCEKT
   301  FGRRHHLIRH QKTHLHDKTS RCSECGKNFR CNSHLASHQR VHAEGKSCKG QEVGESPGTR
   361  KRQRAPPVPK CHVCTECGKS FGRRHHLVRH WLTHTGEKPF QCPRCEKSFG RKHHLDRHLL
   421  THQGQSPRNS WDRGTSVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF641 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 20 nTPM
ovary: 17 nTPM
tongue: 16 nTPM
retina: 16 nTPM
skeletal muscle: 15 nTPM
placenta: 14 nTPM

Single-cell type

neutrophils: 76 nCPM
adrenal cortex cells: 57 nCPM
bergmann glia: 52 nCPM
microglia: 49 nCPM
sertoli cells: 45 nCPM
granulosa cells: 41 nCPM

Immune cell

eosinophil: 7.3 nTPM
neutrophil: 6.6 nTPM
NK-cell: 4.6 nTPM
non-classical monocyte: 4 nTPM
myeloid DC: 3.1 nTPM
classical monocyte: 2.9 nTPM

Brain region

thalamus: 30 nTPM
midbrain: 28 nTPM
medulla oblongata: 27 nTPM
pons: 27 nTPM
white matter: 26 nTPM
hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF641 as an antibody target. Whether an autoantibody or antibody against ZNF641 could matter depends on whether native ZNF641 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF641 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF641 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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