Seroatlas · Human Serome Atlas

ZNF629

Zinc finger protein 629

Also known as: KIAA0326, ZN629_HUMAN, ZNF65

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UEG4
Gene: ZNF629
Ensembl: ENSG00000102870
Chromosome: 16
Canonical length: 869 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

869 residues, UniProt reviewed canonical sequence.

>Q9UEG4|ZNF629
     1  MEPETALWGP DLQGPEQSPN DAHRGAESEN EEESPRQESS GEEIIMGDPA QSPESKDSTE
    61  MSLERSSQDP SVPQNPPTPL GHSNPLDHQI PLDPPAPEVV PTPSDWTKAC EASWQWGALT
   121  TWNSPPVVPA NEPSLRELVQ GRPAGAEKPY ICNECGKSFS QWSKLLRHQR IHTGERPNTC
   181  SECGKSFTQS SHLVQHQRTH TGEKPYKCPD CGKCFSWSSN LVQHQRTHTG EKPYKCTECE
   241  KAFTQSTNLI KHQRSHTGEK PYKCGECRRA FYRSSDLIQH QATHTGEKPY KCPECGKRFG
   301  QNHNLLKHQK IHAGEKPYRC TECGKSFIQS SELTQHQRTH TGEKPYECLE CGKSFGHSST
   361  LIKHQRTHLR EDPFKCPVCG KTFTLSATLL RHQRTHTGER PYKCPECGKS FSVSSNLINH
   421  QRIHRGERPY ICADCGKSFI MSSTLIRHQR IHTGEKPYKC SDCGKSFIRS SHLIQHRRTH
   481  TGEKPYKCPE CGKSFSQSSN LITHVRTHMD ENLFVCSDCG KAFLEAHELE QHRVIHERGK
   541  TPARRAQGDS LLGLGDPSLL TPPPGAKPHK CLVCGKGFND EGIFMQHQRI HIGENPYKNA
   601  DGLIAHAAPK PPQLRSPRLP FRGNSYPGAA EGRAEAPGQP LKPPEGQEGF SQRRGLLSSK
   661  TYICSHCGES FLDRSVLLQH QLTHGNEKPF LFPDYRIGLG EGAGPSPFLS GKPFKCPECK
   721  QSFGLSSELL LHQKVHAGGK SSQKSPELGK SSSVLLEHLR SPLGARPYRC SDCRASFLDR
   781  VALTRHQETH TQEKPPNPED PPPEAVTLST DQEGEGETPT PTESSSHGEG QNPKTLVEEK
   841  PYLCPECGAG FTEVAALLLH RSCHPGVSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF629 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 14 nTPM
heart muscle: 12 nTPM
skeletal muscle: 9.1 nTPM
tongue: 9 nTPM
adrenal gland: 8.4 nTPM
cerebellum: 8.4 nTPM

Single-cell type

myosatellite cells: 14 nCPM
salivary ionocytes: 14 nCPM
alveolar cells type 1: 13 nCPM
megakaryocytes: 12 nCPM
müller glia: 11 nCPM
respiratory deuterosomal cells: 11 nCPM

Immune cell

plasmacytoid DC: 0.6 nTPM
classical monocyte: 0.3 nTPM
NK-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

cerebellum: 18 nTPM
thalamus: 18 nTPM
midbrain: 17 nTPM
medulla oblongata: 17 nTPM
hypothalamus: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.86
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF629 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF629 as an antibody target. Whether an autoantibody or antibody against ZNF629 could matter depends on whether native ZNF629 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF629 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF629 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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