Seroatlas · Human Serome Atlas

ZNF624

Zinc finger protein 624

Also known as: KIAA1349, ZN624_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2J8
Gene
ZNF624
Ensembl
ENSG00000197566
Chromosome
17
Canonical length
865 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

865 residues, UniProt reviewed canonical sequence.

>Q9P2J8|ZNF624
     1  MSLQDSTLSR EGKPEGEIMA AVFFSVGRLS PEVTQPDEDL HLQAEETQLV KESVTFKDVA
    61  IDFTLEEWRL MDPTQRNLHK DVMLENYRNL VSLGLAVSKP DMISHLENGK GPWVTVREIS
   121  RIPYPDMEPK PATKKATRTK AISEDLSQEA ILEKLTENGL WDSRMEGLWK WNDRILRLQN
   181  NQENHLSQRI IPLKKTPTSQ RGFRFESILI PEPGIATEEL HSRCQTQEEN FTENLNLITD
   241  THLGKIICKE MKGSKAIRQT SELTLGKKSN NKEKPYKCST CEKAFHYRSL LIQHQRTHTK
   301  EKPYECNECG KTFSQPSYLS QHKKIHTGEK PYKCNECGKA FIASSSLMVH QRIHTKEKPY
   361  QCNVCGKSFS QCARLNQHQR IQTGEKPYKC SECGKAFSDK SKLARHQETH NGEKPYKCDD
   421  CGKAFRNKSY LSVHQKTHTE EKPYQCNECG KSFKNTTIFN VHQRIHTGEK PFRCNECGKA
   481  YRSNSSLIVH IRTHTGEKPY ECNECGKAFN RIANFTEHQR IHTGEKPYKC NECGKAFINY
   541  SCLTVHHRMH TGEKPYKCTE CGKAFMRSSS LIIHQRIHTE EKPYLCNECG ESFRIKSHLT
   601  VHQRIHTGEK PYKCTDCERA FTKMVNLKEH QKIHTGVKPY KCYDCGKSFR TKSYLIVHQR
   661  THTGEKPYKC NECEKAFTNT SQLTVHQRRH TGEKPYKCNE CGKVFTSNSG FNTHQRTHTG
   721  EKPFKCNDCG KAFSQMVHVT EHQKIHSGEK PYKCDVCGKA FRRGSYLTVH WRTHTGEKPY
   781  TCKECGKGCI TLSQLTLHQR IHTGERPYKC EECGKAFRTN SDFTVHLRMH TGEKPYKCNE
   841  CGKAFRSSSS LTVHQRIHQR ETQLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF624 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
4.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.5 nTPM
  • ovary: 3.5 nTPM
  • spleen: 3.3 nTPM
  • thymus: 2.9 nTPM
  • placenta: 2.8 nTPM
  • retina: 2.5 nTPM

Single-cell type

  • early primary spermatocytes: 24 nCPM
  • oligodendrocytes: 21 nCPM
  • undifferentiated spermatogonia: 17 nCPM
  • bergmann glia: 17 nCPM
  • cone photoreceptor cells: 17 nCPM
  • oligodendrocyte progenitor cells: 16 nCPM

Immune cell

  • intermediate monocyte: 3.3 nTPM
  • naive B-cell: 2.9 nTPM
  • NK-cell: 2.8 nTPM
  • MAIT T-cell: 2.5 nTPM
  • naive CD4 T-cell: 2.2 nTPM
  • eosinophil: 2 nTPM

Brain region

  • white matter: 11 nTPM
  • medulla oblongata: 8.4 nTPM
  • thalamus: 8.4 nTPM
  • cerebral cortex: 7.7 nTPM
  • basal ganglia: 7.5 nTPM
  • pons: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.03
gnomAD missense Z
2.43
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF624 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF624 as an antibody target. Whether an autoantibody or antibody against ZNF624 could matter depends on whether native ZNF624 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF624 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF624 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF624. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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