Seroatlas · Human Serome Atlas

ZNF623

Zinc finger protein 623

Also known as: KIAA0628, ZN623_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75123
Gene: ZNF623
Ensembl: ENSG00000183309
Chromosome: 8
Canonical length: 536 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>O75123|ZNF623
     1  MILLSFVSDS NVGTGEKKVT EAWISEDENS HRTTSDRLTV MELPSPESEE VHEPRLGELL
    61  GNPEGQSLGS SPSQDRGCKQ VTVTHWKIQT GETAQVCTKS GRNHILNSDL LLLQRELIEG
   121  EANPCDICGK TFTFNSDLVR HRISHAGEKP YTCDQCGKGF GQSSHLMEHQ RIHTGERLYV
   181  CNVCGKDFIH YSGLIEHQRV HSGEKPFKCA QCGKAFCHSS DLIRHQRVHT RERPFECKEC
   241  GKGFSQSSLL IRHQRIHTGE RPYECNECGK SFIRSSSLIR HYQIHTEVKQ YECKECGKAF
   301  RHRSDLIEHQ RIHTGERPFE CNECGKAFIR SSKLIQHQRI HTGERPYVCN ECGKRFSQTS
   361  NFTQHQRIHT GEKLYECNEC GKAFFLSSYL IRHQKIHTGE RVYECKECGK AFLQKAHLTE
   421  HQKIHSGDRP FECKDCGKAF IQSSKLLLHQ IIHTGEKPYV CSYCGKGFIQ RSNFLQHQKI
   481  HTEEKLYECS QYGRDFNSTT NVKNNQRVHQ EGLSLSKAPI HLGERSVDKG EHTGNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF623 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 9.1 nTPM
ovary: 7.6 nTPM
skin: 6.8 nTPM
urinary bladder: 6.6 nTPM
colon: 6.5 nTPM
cervix: 6.4 nTPM

Single-cell type

brain excitatory neurons: 20 nCPM
choroid plexus epithelial cells: 19 nCPM
proximal tubule cells: 18 nCPM
microglia: 18 nCPM
brain inhibitory neurons: 18 nCPM
other brain neurons: 15 nCPM

Immune cell

basophil: 1.1 nTPM
naive B-cell: 0.5 nTPM
non-classical monocyte: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
gdT-cell: 0.4 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

hypothalamus: 8.3 nTPM
cerebral cortex: 7.9 nTPM
pons: 7.8 nTPM
amygdala: 7.7 nTPM
hippocampal formation: 7.7 nTPM
medulla oblongata: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF623 as an antibody target. Whether an autoantibody or antibody against ZNF623 could matter depends on whether native ZNF623 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF623 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF623 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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