Seroatlas · Human Serome Atlas

ZNF621

Zinc finger protein 621

Also known as: FLJ45246, ZN621_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSS3
Gene: ZNF621
Ensembl: ENSG00000172888
Chromosome: 3
Canonical length: 439 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q6ZSS3|ZNF621
     1  MLQTTWPQES VTFEDVAVYF TQNQWASLDP AQRALYGEVM LENYANVASL VAFPFPKPAL
    61  ISHLERGEAP WGPDPWDTEI LRGISQGGES WIKNEGLVIK QEASEETELH RMPVGGLLRN
   121  VSQHFDFKRK ALKQTFNLNP NLILRGGMKF YECKECGKIF RYNSKLIRHQ MSHTGEKPFK
   181  CKECGKAFKS SYDCIVHEKN HIGEGPYECK ECGKGLSSNT ALTQHQRIHT GEKPYECKEC
   241  GKAFRRSAAY LQHQRLHTGE KLYKCKECWK AFGCRSLFIV HQRIHTGEKP YQCKECGKAF
   301  TQKIASIQHQ RVHTGEKPYE CKVCGKAFKW YGSFVQHQKL HPVEKKPVKV LGPSLVSPQC
   361  SSPAIPPVLL QGSCSASAVA VPSLTFPHAV LIPTSGNFFM LLPTSGIPSS SAQIVRVFQG
   421  LTPTVKPSPV ILTPSSHSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF621 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 19 nTPM
midbrain: 16 nTPM
basal ganglia: 13 nTPM
amygdala: 12 nTPM
hippocampal formation: 12 nTPM
kidney: 12 nTPM

Single-cell type

myonuclei: 61 nCPM
bergmann glia: 58 nCPM
astrocytes: 54 nCPM
oligodendrocytes: 52 nCPM
podocytes: 51 nCPM
fibro-adipogenic progenitors: 49 nCPM

Immune cell

naive B-cell: 3.3 nTPM
memory B-cell: 2.3 nTPM
basophil: 2.2 nTPM
memory CD8 T-cell: 1.8 nTPM
NK-cell: 1.8 nTPM
naive CD4 T-cell: 1.6 nTPM

Brain region

white matter: 43 nTPM
medulla oblongata: 41 nTPM
basal ganglia: 39 nTPM
thalamus: 36 nTPM
spinal cord: 36 nTPM
hypothalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF621 as an antibody target. Whether an autoantibody or antibody against ZNF621 could matter depends on whether native ZNF621 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF621 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF621 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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